L. Li

This study identifies ORANGE family proteins as regulators of chlorophyll and carotenoid biosynthesis in plants, showing their role in coordinating these pathways for photosynthesis and thermotolerance.

The paper describes synthetic glycans that alter gut microbiome structure and reduce colitis in mice by selectively affecting bacterial growth and metabolism.

This study compares phenotypic and transcriptomic responses of sun- and shade-loving plants to sunlight and dim-light conditions, finding that shade-loving ginseng shows lower phenotypic plasticity but higher photosynthetic efficiency under dim light.

This study develops methacrylate-modified gold nanoparticles (AuMA NPs) to enable non-invasive monitoring of hydrogel scaffolds via X-ray micro-CT.

This study shows that miR-31-5p in psoriatic keratinocytes promotes a metabolic switch to glutamine metabolism, leading to immune-modulatory effects and Th17 cell differentiation, which can be inhibited by GLS targeting.

This study shows that cigarette smoke-exposed T regulatory cells impair macrophage control of Mycobacterium tuberculosis infection in vitro and in vivo.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

This study shows that chronic social stress impairs reward anticipation in mice, but not other reward-related behaviors, and that this effect is influenced by recent reward history and environmental demands.

This study evaluates the functional effects of 21 common sweeteners on human gut microbiomes using metaproteomics, identifying potential prebiotic properties in certain sugar alcohols.

This study shows Epac1 regulates SUMOylation by forming nuclear condensates in response to cAMP, linking stress responses to SUMOylation dynamics.

The paper uses genomic data to show that natural selection and demographic history jointly shaped the genetic structure and contact zones in Norway spruce during post-glacial recolonization.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

This study identifies genetic alterations that enhance the efficacy of ATR and PARP inhibitor combinations while reducing toxicity through CRISPR screens and mechanistic analysis.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

SARS-CoV-2 was detected in one-third of sampled white-tailed deer in Iowa between September 2020 and January of 2021 that likely resulted from multiple human-to-deer spillover and deer-to-deer transmission events.

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

This study shows that gp130/STAT3 signaling is essential for chondrocyte proliferation and anabolism, with loss leading to growth defects and cartilage dysfunction.

The paper identifies a PHYB-PIF4-MYC2 module that regulates secondary cell wall thickening in Arabidopsis under shaded light conditions.

This paper introduces PhoTag, a method to detect cell-cell interactions by labeling cell surfaces with photocatalytic tags, enabling analysis of gene expression differences between interacting and bystander cells.

The paper shows that under high light stress in Arabidopsis, nuclear-encoded enzymes with increased degradation rates are compensated by transcriptional upregulation to maintain proteostasis, while plastid-encoded proteins rely on other mechanisms.

This study evaluates the cultivability and functional activity of biobanked microbiota using an ex vivo assay and metaproteomics, showing stability after long-term freezing.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This study enhances EET in E. coli by implementing the Mtr pathway from Shewanella oneidensis, increasing electroactivity and pollutant degradation.

This paper introduces EEG-AVE, a model that combines EEG signals with audio-visual data to improve cross-individual affective detection performance.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.