L. Yang

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

This study examines seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in a cold temperate zone, finding that altitude has stronger effects than season on community structure and diversity.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

The paper examines cross-reactive serum and memory B cell responses to SARS-CoV-2 and endemic coronaviruses, finding weak serum cross-reactivity but stronger memory B cell cross-reactivity.

This study identifies a single amino acid mutation that determines the difference in neutralization ability of a cross-reactive antibody between SARS-CoV-2 and SARS-CoV.

This study shows methionine synthase (MTR) is crucial for cells to avoid folate trapping and assimilate 5-methyl-THF into other folate species, supporting one-carbon metabolism and tumor growth.

This study shows that the bacterial QS molecule DSF suppresses Arabidopsis innate immunity by altering sterol biosynthesis and disrupting FLS2 receptor dynamics.

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

The paper shows that selection maintains adaptive division-of-labor between tandem duplicates of ATP1A1 in frogs, countering gene conversion to confer toxin resistance.

This study identifies T cell apoptosis and migration as mechanisms of peripheral T cell lymphopenia in severe COVID-19 and links lymphopenia to subsequent T cell proliferation.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

The paper identifies a unique protein architecture in Actinobacteria's -ketoacid dehydrogenase complex, showing a reduced acetyltransferase subunit with implications for drug targets.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

This study shows that YAP, a Hippo pathway protein, promotes melanoma cell invasion and metastasis, with specific target genes mediating these effects.

The paper identifies 5.9% of Type I R-M systems with duplicated hsdS genes that enable phase-variation through recombination, found in pathogens like Enterococcus faecalis and Listeria monocytogenes.

This study shows that brain inflammation leads to macrophage infiltration into the liver via the circulation of inflammatory macromolecules, independent of Kupffer cells.

The paper uses machine learning to predict SARS-CoV-2 inhibitors from FDA-approved compounds, identifying CPI1062 and CPI1155 as potential antiviral drugs.

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

This study shows HSP90 supports metabolic compartmentalization in B-cell lymphomas, and its inhibition reduces cancer metabolism.

The paper models how evolved phenological cueing strategies can lead to variable responses to climate change across different environments.

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

This study shows that auranofin inhibits virulence in Pseudomonas aeruginosa by targeting Vfr, reducing quorum sensing and Type IV pili, and synergizing with colistin to eliminate biofilms.

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.