L. Yang

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

This paper introgresses type-IV glandular trichomes from S. galapagense into tomato, revealing genetic complexity in trichome development and acylsugar production.

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

The paper introduces a single-cell cyclic multiplex in situ tagging (CycMIST) technology to comprehensively profile functional proteins in single neurons, demonstrating its ability to detect 182 proteins in a neuron cell line and reveal differential expression in an Alzheimer's disease model.

The paper identifies 66 compounds that inhibit SARS-CoV-2 replication and 24 that synergize with remdesivir, suggesting potential oral drug repositioning candidates for COVID-19.

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This paper introduces fBSA-Au, a bimodal endocytic tracer for 2D and 3D CLEM, enabling accurate registration of fluorescence to EM data with sub-200 nm precision.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study examines soil bacterial and fungal community patterns and co-occurrence networks along depth and altitude gradients in cold-temperate forests, finding altitude has a stronger impact than depth.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

The paper screens 5440 compounds to identify chemical inhibitors effective against multiple coronaviruses, including SARS-CoV-2, finding several FDA-approved drugs with potential for repurposing.

The paper develops trophoblast and decidua organoids to study antiviral defenses at the maternal-fetal interface, showing differential innate immune responses and susceptibility to HCMV.

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

This study uses paratransgenesis to knock down miR275 in tsetse flies, showing it disrupts midgut physiology and trypanosome infection.

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

This study identifies the Pseudomonas aeruginosa Tat pathway's role in PQS-dependent quorum sensing and biofilm maturation by showing that disruption of the Rieske cytochrome bc1 subunit impairs virulence factor production and eDNA release.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

This study shows alantolactone has antifungal effects against Candida albicans by inhibiting adhesion, biofilm formation, and cell membrane permeability.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study shows that non-enzymatic acetylation of lysine residues in Rubisco activase reduces its stability and ATPase activity under varying light and heat stress conditions.

The paper identifies Treg cell perturbations in severe COVID-19 patients, showing increased FoxP3 levels and pro-inflammatory traits linked to disease severity.