L. Yang

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

The paper shows that heterochromatin in mouse and human cells forms smaller chromatin loops during mitosis compared to euchromatic regions.

This study shows that MyD88 and STING control murine cytomegalovirus in different cell types, with STING also acting in non-hematological stromal cells.

This paper shows that HCFC1 and HCFC1R1 deficiencies block HSV-1 infection by inhibiting nuclear translocation of HCFC1 and VP16, offering potential new therapeutic targets.

This study identifies Lgr5's role in restraining β-catenin to support B-lymphopoiesis and shows its therapeutic potential in B-ALL by targeting β-catenin hyperactivation.

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

This study introduces organ-restricted vascular delivery to enhance nanoparticle targeting to lung tumors, showing improved cellular uptake compared to systemic or intratracheal administration.

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study shows that neuronal lipolysis prevents lipid droplet accumulation and alleviates neurodegeneration in C. elegans by regulating PUFA partitioning and phospholipid incorporation.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

This study shows that population bottlenecks, not epidemic size, primarily influence measles pathogen diversity, and that intermediate vaccination levels paradoxically increase diversity despite reducing incidence.

The paper investigates the relationship between HIF1a and androgen signaling pathways in prostate cancer, finding they operate independently and identify shared genes associated with poor prognosis.

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

This study shows that transient Dux overexpression improves SCNT and chemical reprogramming efficiency, while Dppa2/4 do not, and Dux treatment makes SCNT embryos resemble fertilized embryos.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

This study shows that NK cell inhibitory Ly49 receptors are essential for controlling MCMV infection in an MHC-restricted manner, supporting the missing-self hypothesis.

The paper crosses Pholiota adiposa and P. limonella to develop a high-yield hybrid strain for commercial cultivation.

The paper evaluates how advection and habitat loss interact to affect population persistence in riverine species, finding that restoring flow regimes can reduce persistence in degraded habitats if not paired with habitat protection.

This study shows mutant ACTB mRNA 3'UTR promotes HCC by interacting with miR-1 and miR-29a, leading to increased MET and MCL1 expression.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

This study identifies stable reference genes for RT-qPCR normalization in Hypericum perforatum across tissues, developmental stages, and stress conditions.

The paper compares 3654 chloroplast genomes to uncover evolutionary patterns in green plants, identifying gene clusters and IR expansions.

The paper investigates how adaptive substitutions in Na+,K+-ATPase affect cardiac glycoside insensitivity in insects, revealing epistatic interactions that constrain evolution.