M. Lu

This study uses smFRET to show SARS-CoV-2 variants have more open Spike conformations and slower transitions, increasing their stability and transmission efficiency.

This paper introduces a computational method to analyze high-throughput super-resolution single-particle trajectories, enabling reconstruction of organelle dynamics and membrane reorganization.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

This study identifies AOAH as a lipase that deacylates oxidized phospholipids, reducing inflammation and acute lung injury in vivo.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

This study shows a single dose of the BNT162b2 mRNA vaccine elicits strong antibody and T cell responses, including Fc-mediated effector functions, and boosts pre-existing immunity in previously infected individuals.

This study examines how beta diversity responds to dispersal in meta-community models, finding a hump-shaped relationship influenced by local dispersal, non-neutrality, and biotic interactions.

The paper screens metagenomes for lipolytic genes using function-driven and sequence-based methods, revealing ecological factors influence their distribution.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This paper introduces a parametric framework for quantifying and comparing n-dimensional hypervolumes using multivariate normal distributions, enabling partitioning of niche variation components.

The paper analyzes patterns of vascular plant discoveries in China, finding that socio-economic factors and species traits influence discovery rates and that southwest China harbors the most undiscovered species.

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

This study examines CD8+ T cell cytotoxicity in mild COVID-19 patients, finding reduced cytotoxic potential in elderly individuals over 80 years old.

This paper presents a rapid protocol for purifying monomeric recombinant Aβ from E. coli and fluorescent Aβ-mCherry from mammalian cells, avoiding aggregation and freeze-drying steps.

This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.

This paper characterizes two pectate lyases from Caldicellulosiruptor bescii, showing distinct degradation properties and roles of their CALG domain in plant biomass breakdown.

This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.

The paper identifies Cdc42's role in regulating ESCRT proteins at the nuclear envelope and ER fission sites, impacting nuclear envelope sealing and ER remodeling.

This study identifies C14PC as a potential antivirulence agent against MRSA by protecting immune cells from PVL and -toxin cytotoxicity.

This study evaluates group-level electric field (EF) distribution in deep brain regions during dTMS using different coils, identifying consistent hotspots and providing a method for clinical decision-making.

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

This study shows that dietary methionine restriction affects one carbon metabolism in humans and produces therapeutic responses in cancer by altering metabolic pathways.