P. Zhang

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

This study shows that ER body-resident myrosinases and Trp metabolism shape root microbiota by secreting bioactive metabolites into the rhizosphere.

This paper introduces wide-field plasmonic thermal microscopy (W-PTM) for rapid local temperature regulation and demonstrates its use in modulating TRPV1 ion channels in living cells.

This study determines the structures of perforin-2 in solution and on membranes, revealing its conformational transition mechanism during pore formation.

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

This study enhances flavour profiles in S. pastorianus lager yeast by inducing genomic variation through radicicol-mediated aneuploidy and selection for aromatic amino acid production.

This study shows Aspergillus tabacinus LZ-M can degrade acid red 73 anaerobically through a self-redox mechanism, mineralizing it to CO2 with a 90.28% decolorization rate in 5 days.

The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.

The paper identifies IRI1/LHT1 as the main transporter for beta-amino acids, showing its role in plant resistance and growth trade-offs.

This study uses cryo-electron tomography to reveal the 3D organization of Rubisco in two types of carboxysomes from different bacteria, showing distinct structural arrangements and responses to calcium treatment.

The paper shows that c-Src-dependent phosphorylation of Mfn2 reduces ER-mitochondria distance and enhances Ca2+ transfer, affecting ROS and mitochondrial bioenergetics.

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.

The paper presents cryo-EM structures of BRAF complexes to elucidate how RAS binding initiates conformational changes leading to dimer formation.

The paper identifies candidate virulence loci in Striga hermonthica by analyzing allele frequency differences between resistant and susceptible hosts.

This study develops a metabolitin-based drug delivery system targeting GPR158 in glioblastoma, showing BBB penetration and anti-tumor effects in vitro and in vivo.

This study identifies a core salivary microbiome across human populations using 16S rRNA sequencing, showing stability and variability influenced by geographic location and diet.

This study identifies genomic features of G0 cell cycle arrest in cancer and links it to therapy resistance using transcriptomic analysis and machine learning.

This study develops a hydrodynamic model to explain fish orientation in channel flow, identifying a critical flow speed for successful rheotaxis through bidirectional fluid-fish interactions.

The paper uses high-speed imaging to show that dense core vesicle exocytosis occurs in two distinct modes with different kinetics and regulatory mechanisms.

This study shows AMPK and UPR interact via a positive feedback loop in muscle cells exposed to palmitate, with AMPK agonists enhancing UPR gene expression.

This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.

This study shows that OsLEC1 inhibits photosynthesis in rice embryos to promote seed dormancy by regulating hormonal pathways and gene networks.

This study shows that reducing DAF-2 in the intestine of C. elegans nearly doubles lifespan without affecting development or reproduction.

The paper presents a chromosome-level genome assembly of Thlaspi arvense and uses it to analyze genetic variation and gene structure differences between accessions.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

The paper classifies decidual vasculopathy into types, finding atherosis of trophoblast type is distinct and linked to lower placental weight but not specific clinical features.