P. Zhang

The paper compares decidual vasculopathy in central and peripheral placental regions, finding more vasculopathy in the periphery but more regeneration in the center, with no effect of preeclampsia.

This study identifies hypoxia-targeted mRNAs in cancer exosomes that promote angiogenesis and reprogram recipient cells.

The paper visualizes a novel single-shelled icosahedral intermediate of mammalian orthoreovirus using cryo-electron tomography, revealing structural insights into viral assembly.

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

The paper uses serial cryoFIB/SEM to show cytoarchitectural disruptions in Leigh syndrome patient fibroblasts due to a USMG5 mutation.

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

The paper examines WT1 expression in endometrium across different physiological and pathological conditions, linking it to progesterone effects and gestational vascular changes.

The paper presents a workflow for microED that enables routine atomic structure determination of protein crystals of any size and shape, demonstrated with proteinase K to 2.0 Å resolution.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

The paper identifies the composition and characteristics of lipid droplets in bovine luteal tissue, showing they store cholesteryl esters and triglycerides, and differ from other bovine tissues.

The paper examines fibrinoid deposits in placental tissues during normal pregnancy and complications, identifying CD42b immunostaining as a marker for platelet aggregates and coagulatory cascade activation.

This study shows that reducing rRNA gene copies in Arabidopsis leads to genomic instability, chromosomal duplications, and altered gene expression, including enhanced resistance to pathogens.

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

This paper characterizes the kinetics of the radical-mediated C-C bond formation in MoaA, revealing a shunt pathway and determining the rate of the 3',8-cyclization step.

This study investigates how fungal communities in vineyards influence wine aroma and quality by analyzing microbial distribution patterns across six Australian winegrowing regions.

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This paper expresses two Polydnavirus vinnexin genes in Heliothis virescens caterpillars, showing they disrupt hemocyte function and reduce host viability.

This paper develops a method to selectively deliver volatile anesthetics to the spinal cord in rabbits and shows significant differences in their partial pressures between jugular and femoral veins.

This paper reports on the use of Neo-Islets in pet dogs to treat insulin-dependent diabetes, achieving improved glycemic control without immunosuppression or encapsulation.

This paper introduces NIPSS, a nanopore sequencing method for direct miRNA sequencing, demonstrating single-molecule resolution and potential applications in cancer diagnostics and therapeutics.

This paper investigates the biosynthesis of formycin A and pyrazofurin A, identifying key enzymes and pathways involved in their C-nucleoside scaffold construction.

This paper demonstrates that expressing eight immunomodulatory genes in mouse embryonic stem cells enables them to avoid immune rejection and form immune-privileged tissues in allogeneic hosts.