W. Huang

This paper identifies UGT76B1 as a glycosyltransferase critical for plant immunity by regulating N-hydroxy-pipecolic acid homeostasis, linking its metabolism to defense and growth trade-offs.

The paper shows that static growth in Pseudomonas aeruginosa changes how iron regulates virulence traits and interactions with Staphylococcus aureus through PrrF sRNA and 2-alkyl-4(1H)-quinolone metabolites.

This paper establishes RNAi-based forward genetics in Entamoeba histolytica, identifies slow growth mutants, and characterizes their functional domains and localization.

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

This study shows cingulin regulates apical and tight junction membrane mechanics by organizing myosin-2B and gamma-actin and modulating ZO-1 conformation in MDCK cells.

This paper introduces PrismNet, a deep learning model that uses in vivo RNA structures to predict protein-RNA interactions and identifies disease-associated mutations affecting these interactions.

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

This study examines MHC class II variation in Soay sheep, finding haplotype-specific effects on fitness and suggesting balancing selection and differing mechanisms between juveniles and adults.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

The paper uses single-cell RNA sequencing to study CD8+ T cell differentiation during infection, revealing molecular determinants and functional heterogeneity in tissue-resident memory cells.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study identifies AtCIPK16's role in enhancing salt tolerance in Arabidopsis by regulating phytohormones, transcription factors, and homeostasis.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

The paper maps protein interactions between phytoplasma effectors and Arabidopsis transcription factors, revealing specific targeting of development-related factors and unique infection strategies.

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

This study examines the effect of insulin therapy on OCT/A measurements in diabetic patients without retinopathy, finding thinner MCT and lower PVD in insulin users.

The paper develops a high-affinity sPD-1 decoy molecule that neutralizes both PD-L1 and PD-L2, showing superior antitumor activity in ovarian cancer models compared to PD-1/PD-L1 antibodies.

This study shows that osteopontin (OPN) is more abundant in symptomatic benign prostatic hyperplasia (S-BPH) compared to incidental BPH, and OPN secretion is stimulated by pro-inflammatory cytokines, driving pro-inflammatory gene expression in stromal cells.

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.

This study develops a theoretical framework to model the evolutionary dynamics of extra-chromosomal DNA in cancer, showing that random segregation can lead to complex dynamics even under strong selection.

This study shows Ffar4 resolves inflammation in the heart by sensing fatty acids and promoting anti-inflammatory oxylipin production, preventing cardiac remodeling.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study identifies signature microbiota linked to rumen function shifts in goat kids due to solid diet supplementation using machine learning and functional analysis.

This study shows that miR-15a mimic, especially modified with 5-FU, reduces PDAC cell proliferation and tumor growth, suggesting its therapeutic potential and prognostic value.

This study identifies extracellular heparin-binding proteins (HBPs) in normal and acute pancreatitis mouse pancreas and plasma, revealing their roles in homeostasis and inflammation.

This study uses proteomics to identify iron-regulated processes in Pseudomonas aeruginosa under iron starvation, revealing PrrF sRNA-dependent regulation of amino acid metabolism, iron-sulfur cluster biogenesis, motility, and zinc homeostasis.

The paper identifies Ms4a3 as a marker for tracking monocyte-derived cells and quantifies their contribution to tissue-resident macrophages during homeostasis and inflammation.

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

This study identifies the biosynthetic gene cluster for triacsins in Streptomyces aureofaciens and discovers a new producer species.

This study shows that root VOCs from Centaurea stoebe alter Taraxacum officinale root chemistry and increase herbivore growth.