W. Huang

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

This paper shows that calprotectin induces multi-metal starvation in Pseudomonas aeruginosa through proteomics, revealing non-additive regulatory responses and virulence-related changes.

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

The paper identifies actin polymerization regulators that drive chiral actin swirling and left-right asymmetry in single cells and cell collectives.

The paper examines associations between MHC class II variation and phenotypic traits in Soay sheep, finding links with immunoglobulin levels but not with body weight or parasite egg count.

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

This study shows CBP60b positively regulates SNC2-mediated immunity in Arabidopsis by enhancing SARD1 expression and is required for TIR signaling.

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

The paper shows that an insect beta-glucosidase metabolizes a dandelion defense compound, reducing its toxicity and altering herbivore feeding preference.

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study shows that TIR signaling is essential for enhancing plant defense during pattern-triggered immunity by activating defense genes and increasing resistance to pathogens.

This study predicts opioid kidney clearance and systemic disposition in CKD patients using a microphysiological system and PBPK modeling.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study investigates MHC-dependent sexual selection in Soay sheep using simulations and genetic data, finding pre- and post-copulatory selection and inbreeding avoidance.

This study uses a microfluidic guillotine to analyze wound repair in Stentor coeruleus, revealing three mechanical modes and faster healing rates than previously reported.

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

The paper identifies a peroxidase inhibitor, 6D1, that enhances kanamycin activity against carbapenem-resistant bacteria.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

The paper examines how different subgroups of Aster Yellows phytoplasma progress during the carrot growing season, linking disease dynamics to environmental and agricultural factors.

This study evaluates the effects of 15 bumped kinase inhibitors on zebrafish embryo development and mouse pregnancy, finding limited predictive value of zebrafish tests for pregnancy outcomes.

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

This paper demonstrates a laser-induced cell sorting technique that isolates and cultivates single microbial cells with viability, achieving varying recovery rates across different species.

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

This study investigates platinum resistance in high grade serous ovarian cancer by analyzing transcriptomic features and evolutionary trajectories in resistant models.

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.