W. Song

This study identifies N4BP1 as a dimerization-dependent linear ubiquitin reader that regulates TNFR1 signaling by modulating NF-κB and apoptosis pathways.

This study shows that hepatocyte cholesterol content affects glucagon receptor signaling, with higher cholesterol reducing glucagon's ability to lower blood sugar in NAFLD.

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

This paper introduces a novel algorithm to estimate ants' walking speed and curvature on convoluted trajectories, showing it is more reliable than the conventional SLD method.

PyLipID is a Python package that analyzes protein-lipid interactions from molecular dynamics simulations, identifying binding sites and characterizing lipid interactions.

This study identifies 187 DNA/RNA differences in 36 wheat genes associated with Fusarium head blight, showing their role in regulating FHB response through structural changes and miRNA interactions.

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

This study determines the structure of the Scap/Insig-2 complex in the absence of 25HC, revealing structural insights into cholesterol sensing and regulatory mechanisms.

This study develops a method to determine protein-lipid binding affinities from MD simulations and validates it against experimental and computational methods.

This study shows that Neisseria gonorrhoeae invades non-polarized cervical epithelial cells more efficiently than polarized ones, driven by ezrin phosphorylation and actin dynamics.

The paper demonstrates that focused ultrasound activation of the hepatic neural plexus restores glucose homeostasis in diabetes models across multiple species.

The paper uses molecular dynamics simulations to analyze cardiolipin interactions with 42 E. coli inner membrane proteins, identifying over 700 binding sites and defining metrics for high-affinity cardiolipin binding.

The paper isolates and sequences four novel bacteriophages infecting Klebsiella pneumoniae, revealing low sequence identity to known phages and potential new DNA packaging mechanisms and protein clades.

This study identifies key genes in the polyphyllin biosynthetic pathway using transcriptome and metabolome data combined with phylogenetic analysis.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

The paper develops a BAC-vectored SARS-CoV-2 replicon for antiviral screening and virus-host interaction studies, showing sensitivity to IFN-, remdesivir, and ZAP overexpression.

The paper describes a protocol for gonadectomy and blood sampling in small teleost fish, specifically medaka, to study sex steroid effects on physiology.

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

This paper introduces a label-free imaging cytometry method using deep learning to predict subcellular features from reflectance microscopy, achieving higher accuracy and throughput for single-cell analysis.

The paper shows surface-associated antigen induces B-cell membrane permeabilization and lysosome exocytosis, enhancing antigen uptake and T-cell presentation.

This study uses molecular dynamics simulations to show that GM3 modulates the conformational dynamics of the glucagon receptor ECD and identifies a unique PIP2 interaction profile.

This study uses MD simulations and Markov models to show that A2aR activation increases oligomerisation diversity and connectivity, with PIP2 stabilizing protein interactions.

This study compares the interaction of fresh and aged MoS2 nanosheets with lipid membranes, finding that fresh nanosheets have stronger binding affinity.

This study shows that EphA2 overexpression in NSCLC tumors reduces T cell infiltration and increases myeloid suppressor cells, promoting immune evasion.

This study identifies critical residues in a Dab2-derived peptide that bind sulfatides and inhibit platelet aggregation.

This study introduces a visible light OCTA system for human retinal imaging, achieving high-speed acquisition and microvascular oximetry with sub-100 μm vessel resolution.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

This paper introduces sapphire-supported nanopore membranes with reduced capacitance and noise, improving DNA sensing accuracy and speed compared to silicon-supported nanopores.