X. Li

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

The paper examines ertapenem susceptibility in Neisseria gonorrhoeae isolates from Nanjing, China, showing increasing resistance over time and associations with specific genetic markers.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

This study shows that diet, particularly pollen polysaccharides, has a greater impact on shaping gut microbiomes in Asian honeybees than genetics.

This study shows deep learning can predict multi-omic biomarkers from H&E-stained cancer slides, with 50% of models achieving AUC > 0.633 across 32 cancer types.

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

This study identifies BOS1 as a positive regulator of wounding-induced cell death and plant susceptibility to Botrytis cinerea, showing its role in both fertility and disease response.

The paper isolates and identifies bacterial strains from deep-sea water and sediments in the Mariana Trench, finding that environmental factors shape culturable bacterial diversity.

This paper identifies the conserved intracellular membrane domain (IMD) in Mycobacterium tuberculosis, showing it is a specialized compartment for synthesizing virulence-related lipids.

This study shows that non-canonical NF-kappaB signaling via IKKalpha is essential for MHV68 latency in mice, but not for viral replication or reactivation in all cell types.

The paper validates a deep learning method that predicts breast cancer biomarkers from H&E slides with high accuracy in a clinical setting.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

This paper introduces a method to efficiently enrich cancer-related exosomes using DNA-tetrahedron nanoweights, achieving high sensitivity and specificity in clinical samples.

This study evaluates the PK/PD of LYSC98 against Staphylococcus aureus in a murine model, identifying Cmax/MIC as the best predictor of efficacy.

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

The paper uses coevolution analysis and deep learning to model core eukaryotic protein complexes in yeast, identifying 104 new assemblies and structurally characterizing 608 previously unknown complexes.

This study examines neuromast evolution and distribution in Sinocyclocheilus cavefish, finding asymmetry and convergence in cave-adapted species with distinct wall-following behaviours.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study uses computational models to show that the temporal horn increases hippocampal vulnerability during head impacts by increasing strain and strain rate in specific subfields.

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

This study shows that a single immunization with a vaccinia virus expressing both SARS-CoV-2 spike and nucleocapsid proteins protects hamsters better than expressing either protein alone.

The paper identifies a ROS-Ca2+ signalling pathway through a chemical screen that modifies sugar-activated circadian gene expression in plants.

The paper uses simulations to show that cell adhesion strength regulates non-monotonic growth in multicellular spheroids through a biomechanical feedback mechanism involving pressure fluctuations.

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study investigates vitamin B12 concentrations and tissue distributions in larval and adult Pacific oysters and related bivalves, finding that B12 is not evenly distributed and that larvae may acquire B12 from internal microbiomes rather than diet.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.