Y. Hao

This paper improves QSAR modeling for predictive toxicology by integrating semantic graph data with graph neural networks and analyzing their contributions.

This paper reviews PhD career outcome tracking systems and creates a crosswalk tool to map similarities between taxonomies.

This paper introduces a CRISPR-nCas3 system for efficient genome editing in bacteria, enabling high-efficiency deletion of large genomic regions.

The paper develops a synthetic infection microbiome model to show antibiotics can drive expansion of rare pathogens through competitive release in chronic infections.

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study shows that combining SHP2 and CXCR1/2 inhibitors enhances anti-tumor T cell responses in NSCLC by reducing immunosuppressive gMDSCs and promoting effector T cells.

This paper develops an ultrasensitive biosensor to quantify SARS-CoV-2 RBD and ACE2 interactions in cells and in vitro, enabling rapid evaluation of viral mutants and drug candidates.

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

The paper identifies candidate genes associated with domestication in Brassica rapa and finds that genes from ancient polyploidy are more diverse and linked to domestication.

This study shows ADAR2 promotes Th17 effector function by editing Malt1, leading to increased IL-17A and protection against intestinal inflammation.

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

This study investigates the role of the dorsal premotor cortex (PMd) in hand gesture preparation in macaques, finding that some neurons are involved in hand shape preparation regardless of visual stimuli or selection strategies.

This study identifies SCR's role in promoting root growth by enhancing cell elongation and maintaining redox homeostasis through suppression of oxidative stress response.

The paper determines the spatial arrangement of Sin3 subunits around SIN3A using cross-linking and mass spectrometry, revealing their relative positions and interactions.

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.

This study identifies risk and protective factors for dengue virus infection in Guangdong Province through a case-control study, finding activities in the park, outdoor sports, and poor indoor daylight quality as risk factors, and air-condition use as protective.

This study links high initial abundance of amyloid-producing E. coli, subsequent depletion, and phage activity to type 1 diabetes development in children.

The paper shows dietary fatty acids influence lipid droplet diversity via SEIP-1 enrichment in an ER subdomain in C. elegans and mammalian cells.

This study identifies BmrR as a MarR family regulator that autoregulates the bmrRAB operon in B. longum BBMN68, enhancing bile tolerance through the bile efflux transporter BmrAB.

The paper analyzes bacteriophage composition in PD patients and healthy individuals, finding altered phage/bacteria ratios and depletion of Lactococcus spp. linked to PD pathogenesis.

This study shows C. elegans avoids Pseudomonas aeruginosa by detecting its nitric oxide, with TRX-1 modulating the sensory response through redox sensing.

The paper analyzes genetic data from Yangtze finless porpoises to show population fragmentation, low genetic diversity, and recent decline linked to habitat degradation and human activity.