B. Wang

This paper identifies an N-terminal binding interface on acetylated-α-synuclein monomers that interacts with fibrils and off-pathway oligomers, revealing a mechanism for fibril elongation and potential therapeutic targets.

This study identifies a potent SARS-CoV-2 neutralizing antibody, 5A6, that binds bivalently to two RBDs on the spike protein, showing resistance to key mutations.

This study identifies a cross-regulation mechanism between RpfG and HtsH1/HtsH2/HtsH3 proteins in Lysobacter that controls antibiotic biosynthesis without requiring RpfG's phosphodiesterase activity.

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

This study shows that NAD+ reduction triggers PS exposure and self-destruction in Drosophila sensory dendrites, with phagocytosis driving degeneration and Axed acting in parallel with PS-induced phagocytosis.

The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

This study shows SARS-CoV-2 infection induces a mild type I IFN response in vitro and in moderate COVID-19 cases, and cannot inhibit exogenous IFN induction.

The paper introduces Dropception, a method for high-throughput single-cell encapsulation and phenotyping using double emulsion picoreactors and FACS.

This study shows that CDK4/6 inhibitors induce a non-inflammatory senescent state in non-malignant cells, which lacks the pro-tumorigenic SASP but retains paracrine senescence induction.

The paper shows iron supplementation eliminates antagonistic interactions between root-associated bacteria by revealing iron limitation drives these interactions.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

PRANCE enables feedback-controlled continuous directed evolution of biomolecules through automation, real-time monitoring, and miniaturization, improving efficiency and reducing reagent use.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

This study identifies a partnership between BRD4 and CEBPD that promotes inflammatory SMC state transition and CEBPD transcription in vascular disease.

This paper demonstrates a method to create uniform sub-nanoliter compartments using 3D-structured microparticles, enabling stable monodisperse drops without specialized equipment.

The paper identifies genetic signatures in tumor microenvironments to explain resistance to immunotherapy and suggests potential therapeutic strategies.

The paper identifies molecular signatures of inflamed and non-inflamed tumor microenvironments across cancers and suggests potential drugs to convert non-inflamed tumors to inflamed ones.

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

The paper identifies genes modulating MHC-I and MHC-II expression in lymphomas, revealing potential targets for immunosurveillance manipulation.

This study investigates how angioplasty induces epigenomic changes in rats, revealing BRD4 and EZH2's roles in regulating neointimal hyperplasia through histone modifications.

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

This study identifies collateral fitness effects of mutations in E. coli, showing that 42% of missense mutations in TEM-1 β-lactamase are deleterious through mechanisms unrelated to protein function.

This study shows that ICOS overexpression in mice worsens liver inflammation and fibrosis in Schistosoma japonicum infection by increasing Tfh cell frequency and altering cytokine responses.

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

This study engineers Pseudomonas putida to produce indigoidine with high titer, rate, and yield by coupling product formation with growth through metabolic rewiring and CRISPRi knockdowns.

This study shows that pharmacologic activation of pyruvate kinase (PK) enhances insulin secretion in preclinical diabetes models by stimulating the mitochondrial phosphoenolpyruvate (PEP) cycle.

This paper uses harmonic-balance analysis to model electrode-electrolyte interfaces and optimize stimulus waveforms for neural stimulation within electrochemical safety limits.