C. Gao

This paper develops a pyrF-based genetic manipulation system for Acinetobacter baumannii, enabling efficient marker-less gene editing in multiple strains.

The paper identifies a novel ATP-dependent DMSP lysis pathway in bacteria, revealing a new route in the marine sulfur cycle through the enzyme AcoD.

The paper compares fungal and bacterial diversity in different gut regions of foraging honey bees, finding greater variability in fungi across gut regions and collection sites, suggesting they may be transient rather than functional symbionts.

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

This study identifies TaGS1.1 as critical for nitrogen assimilation and spike development in wheat by analyzing CRISPR-edited mutants and their growth responses under varying nitrogen conditions.

This study identifies SARS-CoV-2 ORF9b as a viral protein that inhibits type I and III interferon responses by disrupting multiple innate antiviral signaling pathways.

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

This study identifies the SARS-CoV-2 M protein as an inhibitor of type I and III interferon production by disrupting RIG-I/MDA-5 signaling, thereby suppressing antiviral immunity and enhancing viral replication.

The paper shows that mIDH1 glioma stem cells secrete G-CSF, which reprograms myeloid cells to become non-immunosuppressive, altering the tumor microenvironment.

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

The paper develops a fluorescent biosensor for L-2-hydroxyglutarate (L-2-HG) using LhgR, a transcription factor that recognizes L-2-HG, and demonstrates its application in monitoring L-2-HG levels in bacterial and human cells.

This paper improves prime editing efficiency in maize by enhancing pegRNA expression for generating double mutations in ALS genes.

This study shows that Tsa1 promotes longevity and H2O2 resistance in yeast by modulating the PKA pathway through redox modifications.

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

This study investigates the ligand specificity of the ATAD2B bromodomain, showing it binds mono- and di-acetylated histones and identifies structural features critical for this recognition.

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

This study identifies sPML-II as the isoform that inhibits PRV infection by suppressing viral gene transcription through its 7b region.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

This study finds that baseline urinary AQP5 levels are independently associated with faster eGFR decline in patients with type 2 diabetes and nephropathy.

This study shows that spotted doves can be infected with SFTSV, with severity depending on viral strain and dose, and suggests they may play a role in virus transmission.

This study identifies the molecular mechanism by which vaccinia virus protein A55 subverts the Cul3 ubiquitin ligase, showing high-affinity binding and structural similarity to cellular BTB-Kelch proteins.

This study characterizes the viral community of the South Scotia Ridge using metagenomic analysis, revealing novel viral sequences and high diversity.

This study identifies and characterizes WRKY genes in melon, analyzes their evolution, and assesses their role in powdery mildew resistance.

This paper describes a bioenzymatic method to synthesize homogeneous human N-glycans from microbial precursors, enabling efficient production of glycan structures for glycoscience applications.