C. Liu

This study reveals the Ca2+ permeation mechanism through RyR1 using molecular dynamics simulations, showing a one-at-a-time hydrated ion translocation pattern.

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

The paper identifies an alternate cell-cycle entry pathway with inverted G1 signaling and a new point of no return, demonstrated through single-cell microscopy in cell lines and mice.

This study compares the mechanisms of three FDA-approved CDK4/6 inhibitors and finds significant differences in their transcriptional, proteomic, and cellular effects, suggesting potential for differential clinical use.

This paper develops a method to use conventional electron microscopes for high-resolution structure determination of small molecules and macromolecules by synchronizing the stage and camera.

This study identifies and validates a novel QTL on chromosome 6HL in barley that confers resistance to Fusarium crown rot, explaining 29.1% of phenotypic variance.

This paper develops a tissue clearing coupled with light sheet fluorescence microscopy method to image coral holobionts at single-cell resolution, revealing endosymbiont distribution and physiological dynamics.

This paper tests the effects of FND-4b, a novel AMPK activator, on breast cancer cell proliferation and apoptosis, finding it reduces growth and increases apoptosis in both estrogen-receptor positive and triple-negative breast cancer cells.

The paper reveals the structure of the chloroplast chaperonin system using Cryo-EM, showing its hetero-oligomeric composition and functional properties.

This study shows that PAKRP2, an orphan kinesin in Arabidopsis, moves processively along microtubules using a noncanonical stepping mechanism with small steps and lateral movements.

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

This study shows MITA regulates BCR signaling through actin reorganization via the PI3K pathway, affecting B cell differentiation and autoimmune disease.

The paper develops a maximum likelihood framework to estimate fitness components in experimental evolution using Drosophila melanogaster data, finding reduced mating preference and viability for a yellow allele.

This study identifies outer membrane vesicles from Lysobacter enzymogenes C3 as vehicles for delivering antifungal antibiotics to fungal targets.

This study measures the load-dependent detachment rate of human β-cardiac myosin at the single molecule level and shows it can be modulated by compounds and mutations.

This paper introduces DO-SRS, a method to visualize metabolic dynamics in living tissues by imaging deuterium incorporation into macromolecules.

This study shows YTHDF1-3 proteins inhibit HIV-1 infection by binding m6A-modified viral RNA, reducing reverse transcription and viral production.

This study investigates how APOBEC3G selects DNA substrates through structural, biochemical, and functional analyses, revealing key interactions and mechanisms involved in its antiviral activity against HIV-1.

The paper discusses challenges in genetic analysis of deep phenotyping projects in common disorders and highlights advances in imputation and GWAS methods to address these challenges.

This study shows that mechanical loading at different stages of cortical bone healing affects repair outcomes, with loading during matrix deposition enhancing bone and cartilage formation.

The paper demonstrates the use of Volta phase plate with Cs-corrected TEM to achieve near-atomic resolution structures of apo-ferritin from over-focused images.