C. Lu

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study compares epigenomic and transcriptomic changes in murine monocytes under low-grade and acute inflammation induced by LPS, identifying pathway-specific responses and epigenetic regulation differences.

This study analyzes spatio-temporal changes in land use and land cover in Bui National Park, Ghana, following hydroelectric dam construction, finding significant increases in built-up areas and water bodies and decreases in forest cover.

This study examines how meteorological factors affect wheat irrigation water requirements in the Beijing-Tianjin-Hebei region from 2000 to 2019, showing trends and correlations with climate variables.

AlphaTracker is a computer vision tool for multi-animal tracking and behavioral analysis, designed for ease of use and real-time performance in studying social interactions in mice.

HOCMO is a tensor-based model that deconvolutes epigenetic microenvironment signals in breast cancer using proteomics data to reveal regulatory dynamics and functional modules.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

This paper tests the hypothesis that Himalayan uplift dispersed aquatic biodiversity by analyzing the phylogeography of Snowtrout fish across Asia.

This study uses single-cell RNAseq to analyze adult Schistosoma mansoni parasites, identifying a key regulator of blood feeding and gut maintenance.

This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

The paper identifies bHLH11 as a negative regulator of Fe homeostasis in Arabidopsis, showing it inhibits bHLH IVc transcription factors by recruiting TOPLESS/TOPLESS-RELATED corepressors.

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.

The paper shows IGF2BP proteins rapidly cluster under osmotic stress, initiating stress granule formation before other proteins, and identifies the molecular mechanisms involved.

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

The paper uses CRISPR-Cas9 screens in isogenic ccRCC cell lines to identify synthetic lethal partners of VHL, revealing new therapeutic targets for renal cell carcinoma.

This study designs and evaluates TRAP-CSP fusion antigens as malaria vaccines, finding that those containing the CSP repeat region provide complete sterile protection in mice.

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

This study identifies LRRC33 as a novel TGF-β1 binding and regulating protein in AML cells, showing its correlation with TGF-β1 expression and its role in TGF-β1 activation.

This paper constructs a synthetic inducible promoter by analyzing the 39K promoter of BmNPV and identifies key regulatory regions for virus-inducible activity.

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.

This study characterizes the structure, function, and dynamics of the gamete fusogen HAP2, revealing dynamic regions and structural features critical for fusion.

This study identifies cytarabine as a potent inhibitor of KSHV-induced primary effusion lymphoma by targeting both viral and host DNA/RNA synthesis and inducing tumor regression in a xenograft model.

The paper determines the structure of pro-TGF-β1 with a cleavage site mutation, revealing prodomain-GF domain swapping in the dimeric structure and its implications for TGF-β biosynthesis.