C. Zhang

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

The paper identifies a bacterial toxin immunity gene acquired by gut fungi through horizontal gene transfer, providing evidence of its role in fungal survival in the gut microbiome.

The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.

This study shows that glioma stem cells exhibit optimal migration at specific matrix stiffness, mediated by MGAT5-dependent N-glycan branching.

This paper benchmarks clonal tree reconstruction methods using a scalable model of antibody evolution and finds that simple postprocessing improves accuracy over alternative methods.

The paper identifies ubiquitylated proteins in Arabidopsis during MAMP-triggered immunity, revealing the ubiquitin-proteasome system's role in immune regulation.

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

This study shows that myogenic vasoconstriction in mice depends on Gq/11 signaling through AT1aR, not β-arrestin-mediated pathways.

The paper develops a 3D organoid sarcoidosis model using patient-derived granulomas and microfluidics to study cytokine profiles in a lung-on-chip system.

This study identifies the role of forehead gland secretions in conflict resolution among male Great Himalayan leaf-nosed bats through chemical analysis and behavioral experiments.

This paper identifies potent SARS-CoV-2 neutralizing nanobodies, develops multivalent cocktails with high neutralization potency, and highlights their therapeutic potential.

This study shows that exogenous calcium is toxic to fungal cells lacking calcineurin, a key calcium regulator, and that this toxicity is linked to cytosolic calcium overload and vacuolar storage deficits.

The paper identifies a scaffold-scaffold interaction in Caulobacter crescentus that regulates PopZ localization and cell polarity during division.

This study investigates the anti-inflammatory effects of MIA602, a GHRH antagonist, in sarcoidosis by analyzing its impact on cytokine levels and cellular markers in vitro and in vivo.

This study shows Arabidopsis myosin XIK interacts with the exocyst complex to facilitate vesicle tethering during exocytosis, revealing a role in secretory processes in plants.

This study identifies structural defects in ZIP4's extracellular domain caused by AE mutations, leading to mistrafficking and loss of zinc uptake.

The paper investigates age-related resistance to Phytophthora capsici in cucumber fruit, identifying early transcriptional and biochemical changes that enable rapid pathogen inhibition.

This study shows that lipid droplet dynamics can quantify cellular metabolic changes by analyzing their displacement, speed, and directionality using label-free microscopy.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

This study identifies Aqp5 as a key factor in IPMN development using a novel mouse model, linking nuclear GSK-3β and oncogenic KRas to terminal duct cell expansion.

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

The paper presents a near-complete yeast proteome dataset using optimized sample preparation and high-resolution mass spectrometry, identifying 5610 proteins with 94.1% coverage of yeast ORFs.

This paper evaluates FL2-NPsi, a nanoparticle-encapsulated siRNA targeting FL2, in a rat model of corneal alkaline burn, finding it enhances wound healing without toxicity.

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

This study shows that coronatine, a bacterial toxin, more effectively regulates the Arabidopsis circadian clock than plant-derived jasmonates.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

This study synthesizes and evaluates drimane sesquiterpenoids for antifungal activity, identifying drimenol as a broad-spectrum antifungal agent effective against multiple fungal species and resistant strains.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study shows that Ca2+ and H+ transport across the yeast vacuole membrane are reciprocally regulated and linked to Phosphatidylinositol 3,5-bisphosphate production.