C. Zhang

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

This study shows that a common SEC23B mutation in mice causes chronic pancreatitis and growth restriction, highlighting SEC23B's role in pancreatic function and growth hormone sensitivity.

This study evaluates antibiotic concentrations affecting gut bacteria and Ectropis obliqua growth, finding 300g/ml effectively clears bacteria without harming growth.

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.

This study identifies UCHL1's role in maintaining protein homeostasis in HGSOC via the PSMA7-APEH-proteasome axis, showing its importance for tumor growth and suggesting therapeutic targeting.

This paper introduces an optimized 3D single-particle tracking system using off-center sampling to improve localization precision by efficiently utilizing photons.

This study shows that Withaferin A promotes white adipose browning and prevents obesity by activating the Prdm16-FATP1 pathway via the sympathetic nervous system.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

The paper introduces a method to infer species trees while accounting for gene flow, showing improved accuracy in species history reconstruction for mosquitoes.

The paper identifies accelerated evolution in the Nrk gene's exons in eutherian mammals, suggesting a new exon ignited positive selection linked to placental development.

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

The paper identifies ATF3 as a key driver of chromatin accessibility remodeling during senescence, linking it to the regulation of senescence programs.

This study develops a method for isolating and cryo-preserving pig skin cells for scRNA-Seq, enabling the identification of major skin cell types.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

This paper introduces a reagent-free imaging platform combining Raman microscopy and quantitative phase imaging to distinguish stages of B-cell acute lymphoblastic leukemia.

This study shows that Matriptase promotes tissue damage responses by activating Gq signaling, leading to RSK and DUOX activation, which disrupts epithelial junctions and contributes to inflammation and carcinoma.

This study identifies two pathways, SIK activation by salt stress and IRE1-dependent ATP depletion, that together induce Sec body formation in Drosophila cells under amino-acid starvation.

This study maps the cellular dynamics and intercellular interactions in a mouse liver transplant model using single-cell RNA sequencing and CyTOF, revealing recipient cell dominance and macrophage-driven metabolic remodeling.

This study identifies Subgroup 2 R2R3-MYBs as key regulators of the stilbenoid pathway in grapevine by integrating DAP-Seq and co-expression networks.

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

This study shows that 1 μM Dexmedetomidine reduces H9C2 cardiomyocyte injury under hypoxia/reoxygenation by partially inhibiting endoplasmic reticulum stress.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

This study investigates the genetic and physical interactions between SQUAMOSA and SVP MADS-box proteins in wheat spike development, showing their roles in regulating meristem transitions and floral development.

This study shows that bile acid overload in a mouse model impairs brown adipose tissue thermogenic function, with mitochondrial dysfunction and senescence gene induction.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

This paper identifies how GCRV proteins interact with fish RLR factors to suppress MAVS-TBK1 signaling and reduce IFN expression, revealing a unique fish virus evasion mechanism.

The paper identifies conserved regions in SARS-CoV-2 with high base order-dependent folding energy, suggesting they may be potential therapeutic targets similar to HIV-1.