F. Wang

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study identifies Cdc14 as a meiosis-specific autophagy regulator that controls spindle pole body dynamics by dephosphorylating Atg13 and promoting autophagy during anaphase I and II.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

This study evaluates a multivalent Ad-vectored vaccine delivered via respiratory mucosal route, showing robust protection against SARS-CoV-2 and variants in mice.

This study investigates transcriptional heterogeneity in Aspergillus fumigatus strains responding to caspofungin, identifying a core response and variable response linked to secondary metabolite biosynthesis and iron homeostasis.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

The paper isolates and characterizes a Cyprinid herpesvirus strain YZ01 from goldfish exposed to elevated water temperatures, showing high genomic similarity to other C genotype strains.

This study shows that activating P2Y1 receptors enhances arterial function in conditions where endothelial autophagy is suppressed.

This study identifies proteins interacting with EGFR during C. albicans infection and shows that gC1qR is essential for EGFR signaling and immune responses.

This study screens 1,127 compounds against Aspergillus fumigatus, identifies miltefosine as fungicidal, and reveals RmiA as a transcription factor regulating sphingolipid biosynthesis involved in miltefosine resistance.

This paper introduces 3D-EPTI, a novel MRI technique that enables ultrafast multi-parametric quantitative imaging with high resolution and efficiency.

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

This study presents cryo-EM structures of the HER2/HER3 receptor complex bound to NRG1β, revealing conformational dynamics at the dimerization interface and how mutations and therapeutics interact with this interface.

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.

This study compares two processing tomato cultivars under heat stress, finding that yield differences are not linked to pollen viability, suggesting other factors are key to heat tolerance.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

This study characterizes the airway bacterial and fungal microbiome in COPD patients and healthy controls, finding altered microbial diversity and interactions associated with disease severity.

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This study identifies oxysterol derivatives with anti-SARS-CoV-2 activity, showing that Oxy210 and Oxy232 inhibit viral replication by disrupting double membrane vesicles.

This study shows that Hedgehog pathway inhibitors reduce heterotopic ossification in a trauma/burn mouse model by inhibiting osteoblast differentiation and systemic inflammation.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.