F. Wang

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

This study reveals how Yta7 ATPase disassembles nucleosomes by unfolding histone H3 through a rotary staircase mechanism involving its BRD and AAA+ modules.

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

This study determines the atomic structure of archaeal bundling pili from Pyrobaculum calidifontis, revealing structural and mechanistic similarities to bacterial biofilm components.

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

This study uses single-cell and bulk RNA sequencing to identify cellular changes and interactions in necrotizing enterocolitis, highlighting inflammatory macrophages, T cells, and epithelial-mesenchymal-immune interactions.

The paper constructs a well-resolved Amoebozoa phylogeny using conserved genes, revealing novel relationships and resolving enigmatic lineages, and hypothesizes evolutionary drivers linked to microbial mat grazing.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

This study examines the bioaccumulation and immune response of sea cucumbers exposed to chronic dietary hexavalent chromium, finding tissue-specific accumulation and altered enzyme activities.

This study examines how chronic intermittent hypoxia and chronic sleep fragmentation affect gut microbiota, serum metabolites, and tissue morphology in mice, revealing their impact on lipid metabolism.

This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

The paper shows that kidney cells reprogram iron metabolism to prevent severe malarial anemia by supporting erythropoiesis.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

This study shows Hantaan virus uses mitochondrial OXPHOS for replication, driven by AKT activation and PNPT phosphorylation.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

This study evaluates two wearable face and neck cooling fans to improve indoor thermal comfort and reduce HVAC energy use in warm conditions.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This study identifies HOXB13's AR-independent role in suppressing lipogenesis via HDAC3-mediated epigenetic repression, linking its loss to metastatic prostate cancer progression.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

This study identifies α-taxilin and γ-taxilin as new components of centriolar subdistal appendages, showing their role in microtubule anchorage and spindle orientation.

This study investigates the roles of Haspin and VRK1 in phosphorylating histone H3 during mitosis, finding that VRK1 does not directly phosphorylate H3T3 or H3S10, while Haspin is essential for H3T3ph.

This paper introduces ACE-EPTI, a diffusion MRI technique that improves SNR efficiency and reduces distortion, achieving high-resolution, multi-TE images with 3-shot acquisition.

This paper develops a non-invasive imaging technique using NIR-IIc light to image deep tissues in mice, achieving imaging depths of ~800 m and visualizing immune structures in lymph nodes.