H. Jiang

This study compares tree-based and pixel-based remote sensing approaches for mapping forest functional traits and diversity, finding that tree-based methods better capture trait variation at high resolution.

The paper presents the cryo-EM structure of the chicken CENP-A nucleosome complexed with ggKNL2, revealing how ggKNL2 recognizes CENP-A and facilitates its deposition.

This study shows that substrate adhesion controls mesenchymal cell migration and condensation during chondrogenesis by modulating migration modes and cell-cell interactions.

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.

This study engineers a relaxin-2 variant with a longer serum half-life by fusing it with an antibody Fc fragment, maintaining RXFP1 agonist activity in vitro and in vivo.

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

This study shows that in pulmonary arterial smooth muscle cells, HIF upregulates AQP1 protein through Ca2+ elevation rather than direct transcriptional regulation.

The paper shows that TMYX slows pacemaker cell rate by antagonizing cAMP-induced modulation of f-channels, similar to muscarinic stimulation or beta-blockers, but without affecting overall cAMP levels.

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

This study shows that Bmal1 regulates the rhythmic cell cycle progression and lipid accumulation in hepatocytes during liver regeneration, with disruptions in Bmal1 leading to delayed DNA synthesis, loss of mitotic oscillation, and altered redox state.

This paper introduces a cyborg brain organoid platform for long-term 3D electrophysiological recording, enabling continuous monitoring of single-cell action potentials during brain organoid development.

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

This study shows activin B promotes liver fibrosis initiation and progression by acting on hepatocytes and hepatic stellate cells, and its neutralization prevents and regresses fibrosis in mice.

This study shows that Ascl1 activation in maternal liver during pregnancy supports healthy pregnancy outcomes by coordinating maternal organ adaptations and placental growth.

This study shows that Nrf2 deficiency leads to hepatocyte dedifferentiation and reduced albumin production in a cholestasis model.

The paper simulates fluorescence imaging in the oral cavity using a 3D model and compares simulated data with real camera data to quantify porphyrin fluorescence relative to other fluorophores.

This study shows that stromal collagen structures in pancreatic ductal adenocarcinoma promote early dissemination from pre-malignant lesions and ongoing invasion, suggesting FAK inhibition or stroma normalization could limit metastasis.

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

This study identifies two heat stress-responsive NAC transcription factors in rice that regulate grain filling and sugar transport through a heterodimer complex.