H. Jiang

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

This study shows that a plant-antagonistic bacterium can evolve into a mutualist in the Arabidopsis rhizosphere within six months through genetic changes enhancing competitiveness and plant signaling activation.

This study uses experimental evolution to identify 35 mutations in 28 genes that enhance Pseudomonas protegens' ability to colonize the Arabidopsis thaliana rhizosphere.

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

This study investigates how the intracellular localization of Mycobacterium tuberculosis affects the efficacy of the antibiotic pyrazinamide (PZA) using multimodal microscopy techniques.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

This study analyzes fecal microbiota composition in CRC patients and identifies Fusobacterium as a potential biomarker for CRC screening in Chinese populations.

The paper develops a genomic resource of 1,500 soybean genomes with 32 million SNPs to enable post-genomic research and applications like QTL discovery and trait allele identification.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study shows that combining MEK inhibition, autophagy inhibition, and CD40 agonism activates the Type I Interferon/STING pathway in PDA tumors, reprograms TAMs, and enhances anti-tumor immunity in a mouse model.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

The paper discusses the adoption and misuse of Open Science principles during the COVID-19 pandemic and advocates for their wider implementation to ensure rigorous and transparent research.

The paper uses CLEIMiT to show bedaquiline accumulates in specific cell types in M. tuberculosis infected lungs.

This study identifies SvFUL2, an A-class MADS-box transcription factor, as essential for inflorescence determinacy in Setaria viridis, showing that its disruption leads to indeterminate inflorescence and altered meristem behavior.

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study identifies MdPAT16 as a palmitoyltransferase that enhances salt resistance and regulates apple sugar content through the MdCBL1-MdCIPK13-MdSUT2.2 pathway.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

This paper develops FeADCs, ferrous iron-activatable drug conjugates, to target KRAS-driven cancers with improved tumor selectivity and systemic tolerability.

This study shows that BMP9 protects pulmonary endothelium during inflammation-induced lung injury and that exogenous BMP9 can prevent lung injury in mice.

This study maps the human nuclear cap-binding complex interactome using affinity proteomics to clarify the composition and interactions of NCBP1, NCBP2, and NCBP3-related macromolecular assemblies.

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.