H. Zhao

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

This study investigates how SARS-CoV-2 N-protein interacts with nucleic acids to form supramolecular clusters and phase-separated droplets, revealing structural and energetic changes during assembly.

This study evaluates the effectiveness of Spray-Induced Gene Silencing (SIGS) by assessing RNA uptake efficiency in various eukaryotic microbes and its impact on plant disease control.

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine protects against SARS-CoV-2 infection in rhesus macaques by inducing neutralizing antibodies and T cell responses.

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

This study analyzes KSHV genome variability in Ugandan HIV-associated KS patients, finding high homogeneity within individuals but tumor-specific mutations and inactivations.

This study shows that TFH-B cell interactions driven by neoantigens enhance anti-tumor CD8+ T cell responses in lung adenocarcinoma.

Biochemical and transgenic analyses reveal that Petunia hybrida S3-RNase cytotoxicity is largely restricted by a stepwise ubiquitination and degradation pathway during cross-pollination.

This study shows that condensins SMC and MksBEF in Pseudomonas aeruginosa are essential for corneal virulence by regulating gene expression programs involved in metabolism, virulence factors, and bacterial lifestyle.

This study compares intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine in hamsters, finding that intranasal immunization provides superior protection against infection and inflammation.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

This study presents a molecular model of mammalian Mediator complex using cryo-EM, revealing the structure of the previously unresolved Tail module and its interactions with core Mediator.

This study investigates how day length affects flowering time in Miscanthus and sugarcane to enable synchronized hybridization, finding that day length requirements vary by species and geographic origin.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

The paper introduces CRSO to identify cooperating driver combinations in cancer, finding 11 core combinations per cancer type with clinical relevance.

This study shows that fecal microbiota transplantation (FMT) restores gut microbiota balance and protects the intestinal barrier in septic mice by enhancing short-chain fatty acid production.

This study investigates the roles of SMC and MksBEF condensins in chromosome organization and segregation in Pseudomonas aeruginosa, revealing their distinct and coordinated dynamics.

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

This study shows androgen signaling increases ACE2 levels, contributing to severe COVID-19 in men, and suggests androgen receptor inhibition as a potential treatment.

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

The paper identifies stromal genes differentially expressed in lobular breast cancer, highlighting pregnancy-associated-plasma protein-A (PAPPA) as a potential prognostic marker.

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.