H. Zhao

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This paper introduces a dynamic aqueous multiphase reaction system for rapid, sensitive, and quantitative CRISPR-Cas12a-based molecular diagnosis of HPV16/18 DNA.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study shows ARHGEF3 promotes muscle regeneration and strength by enhancing autophagy, independent of mTORC2-Akt signaling, in both young and aged mice.

The paper develops a robust ChIP protocol that significantly improves enrichment fold in birch and Arabidopsis, and is applicable to both woody and herbaceous plants.

This study investigates LINC00152's role in esophageal adenocarcinoma, finding it promotes tumor progression via STAT3 and c-MYC signaling and suggests it as a biomarker and therapeutic target.

The paper analyzes transcriptomic and proteomic data from a new cytoplasmic male sterile cotton line to identify differentially expressed genes and proteins involved in microspore abortion.

This study shows LRRK2 and Rab10 coordinate macropinocytosis in phagocytes, with LRRK2 phosphorylating Rab10 to block cargo recycling and promote signaling endosome maturation.

This study shows that Cep57 and Cep57l1 recruit the Cep63-Cep152 complex to mother centrioles, enabling centriole duplication.

This study traces the evolutionary origin of the Hippo pathway from unicellular ancestors and examines its oncogenic alterations in mammals.

The paper engineers the auroramycin biosynthetic pathway in Streptomyces roseoporous to identify key structural features responsible for its antimicrobial activity.

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

This study shows that an antisense oligonucleotide reduces Hdac2 mRNA and enhances memory in mice by inhibiting RNA polymerase II elongation.

This study shows that combining sirolimus and nintedanib treats vascular abnormalities in HHT mouse models by targeting multiple pathways.

The paper generates a comprehensive Arabidopsis proteome atlas and library, then uses DIA-MS to study abscisic acid effects, identifying differentially expressed proteins.

This study uses molecular dynamics simulations to analyze the thermodynamic and dynamic properties of canonical and CENP-A histone tetramers, revealing structural differences and their implications for nucleosome assembly.

The paper shows TAp73 and miR449 work together to support multiciliogenesis, with their combined loss causing brain defects and hydrocephalus.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

The paper shows that mother centrioles are not required for deuterosome formation and function during basal body amplification in multiciliate cells.

This study identifies AtERG2, a mitochondrial GTPase in Arabidopsis, as essential for early embryo development, with mutants showing seed abortion and ROS accumulation.

The paper introduces SHACKTeR, a method for live cell imaging of specific chromosomal regions using CRISPR/Cas9 and TetO repeats, successfully labeling 9 loci in HCT116 cells with up to 20% efficiency.

This study identifies tacrolimus as a drug that activates Smad1/5/8 signaling and reduces vascular pathology in HHT models.

The paper investigates gene expression variations in yeast and finds most are neutral, not adaptive, suggesting random mutations drive expression evolution.

This study uses transmammary delivery of anti-BMP9/10 antibodies to induce HHT-like vascular defects in mouse neonates, revealing consistent retinal pathology and increased angiopoietin-2 expression.