J. Xie

This study shows that APOBEC mutagenesis in breast cancer promotes T cell-mediated antitumor immunity, leading to tumor growth inhibition and sensitivity to checkpoint inhibitors.

The paper shows that loss of PABPC1 increases PABPC4 levels and alters key transcriptional regulators in HEK293 cells.

This study identifies Paip2 as a protein that interacts with PABPC1 on mRNA and may help PABPC1 detach from mRNA during deadenylation.

The paper shows PABPC1 is essential for P-body formation despite not being present in P-bodies, and demonstrates GW182's role in mediating this process.

This study shows alantolactone has antifungal effects against Candida albicans by inhibiting adhesion, biofilm formation, and cell membrane permeability.

This study shows that energy expenditure during cell spreading on stiff substrates affects stem cell responses to matrix stiffness via AMPK activation.

This paper develops a robotic platform with tactile sensing and machine learning to digitize and classify 3D human pulse patterns, achieving 98.7% and 84.2% classification rates for three TCM pulse types.

This study identifies JAM2 as a prognostic marker and potential predictor of immunotherapy response in breast cancer using multi-database analysis.

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

The paper uses single-cell multi-omics to analyze HCC cell lines, identifying metastasis potential heterogeneity and a hypoxic subgroup with poor prognosis.

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

Optical topometry and machine learning tools were developed to assess epidermal cell patterning, and applied to analyze its genetic architecture alongside leaf photosynthetic gas exchange in maize.

This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.

This study shows that eEF2K enhances PD-L1 expression by promoting its mRNA translation through a uORF in the 5-UTR, making cancer cells more vulnerable to immune attack.

This paper develops a Mask R-CNN model to automate counting reproductive structures in herbarium specimens, achieving high accuracy for buds and fruits but lower for flowers.

The paper reports the cryo-EM structure of human NALCN with FAM155A, revealing interactions and ion-binding sites that inform Na+ permeation and disease mechanisms.

This study identifies Rac1/ROCK-driven membrane dynamics as a mechanism promoting necroptosis in NK cell cytotoxicity, enhancing target selectivity in cancer.

The paper constructs atomistic ensembles of the SAM-responsive riboswitch in the presence and absence of SAM using solvent accessibility data, revealing structural changes and a hidden binding pocket.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This study examines the effects of atrazine exposure on DNA methylation and gene expression in zebrafish, identifying specific genes and pathways affected by the herbicide.

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.

The paper evaluates genetic barriers to resistance against broadly neutralizing antibodies targeting the stem region of influenza H3 and H1 hemagglutinins, finding H3 has lower resistance barriers.

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.