L. Wang

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

This study finds that quantitative susceptibility mapping (QSM) correlates with cardiovascular risk factors and white matter hyperintensities in HIV-infected and uninfected individuals, suggesting QSM as an early marker of brain microcirculation changes.

This study meta-analyzes 193 studies to compare single visit pollination effectiveness across plant visitors, finding honeybees are less effective than many non-honeybee pollinators.

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

This study shows TPD52 inhibits AMPK activity, leading to metabolic defects in mice, highlighting its role in cancer metabolism.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

The paper examines drug sensitivity variations among C. elegans DEG/ENaC/ASIC channels, showing some are insensitive to amiloride and NSAIDs can inhibit or potentiate them.

This study develops a 3D airway epithelial ALI model to study coronavirus infection and drug efficacy, finding it mirrors human airway responses and drug effects.

This study shows that using the same calibration materials and points improves interlaboratory and inter-platform comparison of fluorescent submicron particles.

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

The paper determines the structure of the SARS-CoV-2 E protein-PALS1 complex using cryo-EM, revealing a hydrophobic interaction that explains viral spread and suggesting therapeutic targets.

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

This study identifies BREVIPEDICELLUS and ERECTA pathways that prevent Arabidopsis callus browning by regulating AtPRX17 expression.

The paper develops a FRET biosensor using intrinsically disordered proteins to monitor osmotic stress effects across multiple organisms.

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

This study demonstrates that pericyte-like cells in cortical organoids can support SARS-CoV-2 infection and replication, serving as a new model for neural infection.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

The paper identifies hyperactive antibody responses and vascular pathology in metabolic-active lung tissues of tuberculosis patients, sharing features with autoimmune diseases.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

This study identifies replication stress in premalignant OPCs before glioma formation using stochastic profiling in a mouse model.

This study identifies variation in Leishmania chemokine suppression linked to GP63 diversification, showing how parasite genetic differences affect immune response outcomes.

The paper characterizes the transcriptional and epigenomic response of human tubular epithelial cells to serum exposure, identifying key regulatory programs and gene signatures.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

This study identifies an introgression from teosinte mexicana that affects HPC1, modulating phosphatidylcholine levels and influencing maize flowering time under low-temperature conditions.

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.

The paper develops a CRISPR/Cas9-based tool to induce targeted and tunable DNA double-strand breaks in human cells for studying repair mechanisms.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

The paper uses molecular dynamics simulations to analyze lipid fingerprints of SLC6 transporters in neuronal membranes, finding that lipid composition and interactions vary between transporters and affect membrane properties.