L. Wang

The paper introduces membrane contact probability (MCP) as a predictive metric for membrane proteins, showing it improves contact map and structure predictions.

This paper develops a method for high-resolution deep brain imaging in mice using adaptive optics three-photon microscopy and demonstrates its ability to image deep cortical structures and astrocyte calcium transients.

This study uses post-translational knockdown and post-secretional inhibition of EsxA to confirm its membrane-permeabilizing activity is essential for mycobacterial virulence without confounding genetic compensation effects.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

The paper quantifies cellular density and clustering of immune cells in metastatic ccRCC and finds that CD68+ TAM clustering with tumor cells correlates with worse overall survival.

This study evaluates SARS-CoV-2 susceptibility in cell lines used for influenza and other virus diagnosis, finding that some are permissive while others are not, with MDCK cells being insusceptible due to low ACE2 expression.

This study identifies ARHGEF26 as a host factor that enhances Salmonella invasion and inflammation through interactions with DLG1 and SCRIB, and shows its role in murine infection models.

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study shows that eIF2B assembly and conformation regulate the ISR, with ISRIB affecting eIF2B through decamer stabilization and allosteric modulation.

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

This study evaluates DHEA extract from sweet potato on C. elegans lifespan, finding it extends life by 13.60% but not via calorie restriction, and suggests antioxidant and daf-16 activation mechanisms.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

The paper identifies a novel dermal migratory Langerhans-like cell population using fate mapping and single-cell RNA sequencing, showing distinct migration and replenishment characteristics compared to Langerhans cells.

This study investigates how HIV-1 Env is recruited and retained at the virological synapse through targeted recycling rather than irreversible interactions.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

This study shows that loss of CASP8 function combined with SMAC mimetic treatment increases necroptosis in HNSCC, enhancing radiation sensitivity.

The paper confirms the establishment of Culex modestus in Belgium and identifies its virome, highlighting the risk of arbovirus transmission.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study presents the structure of primate ferroportin and elucidates its mechanism of iron transport and regulation by hepcidin.

This study investigates how HIV-1 Nef's flexible regions interact with its core domain to influence SH3 domain selectivity and identifies few human proteins with similar binding properties.

The paper examines how TCRB repertoire features change with CD4+ T cell differentiation and finds that public clones decrease in differentiated subsets, reducing antigen specificity.

This study investigates how BBS mutations affect neuron function and signaling in iPSC-derived neurons, identifying impaired ciliary function and signaling pathways related to energy homeostasis.

The paper uses molecular and morphological data to clarify species boundaries in Betula section Costatae, identifying a new species, Betula buggsii, within the group.

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.