L. Wang

This study determines the crystal and cryoEM structures of ALC1 and its nucleosome-bound form, revealing the autoinhibition mechanism and activation by the nucleosome.

This study identifies RBP45D as an RNA-binding protein involved in DCL3-independent RNA-directed DNA methylation and flowering time regulation in Arabidopsis.

This study compares the in vitro antifungal activity of SHR8008, a novel tetrazole, to itraconazole and fluconazole against Candida and Cryptococcus species, finding SHR8008 to be significantly more potent.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

A strain-programmable bioadhesive patch accelerates wound closure and healing in diabetic mice and human skin.

This study shows that SFSV NSs protein evades the ISR by competing with eIF2-P for binding to eIF2B, preserving its activity and allowing viral protein synthesis.

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

This paper develops a RPA-Cas12a fluorescence assay for rapid, accurate detection of zoonotic dermatophytes with high sensitivity and specificity.

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

This study uses DNA barcoding and molecular phylogenetics to revise the genus Dichaetophora, identifying cryptic species and taxonomic issues within the group.

This paper introduces SEER-FISH, a method for spatially profiling microbial communities with high multiplexity and accuracy, demonstrating its ability to quantify taxon abundance and map microbial biogeography.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

This paper describes a method to systematically tune the spirocyclization equilibrium of rhodamines to create probes for different super-resolution microscopy techniques.

This study assesses the durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants over seven months, finding persistent but reduced binding and functional responses.

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

This study shows that IRX3 in uterine stromal cells promotes vascularization during embryo implantation, supporting successful pregnancy.

This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

A synthetic peptide vaccine targeting SARS-CoV-2 nucleocapsid protein protected rhesus macaques from viral challenge, reducing pneumonia and viral load.

The paper defines the role of wild-type and patient-specific TP53 mutations in ERMS using zebrafish models, showing tp53 loss increases tumor initiation and identifying mutation-specific effects on tumor development.

This study identifies EXOSC1 as an endogenous source of mutation in KIRC that promotes DNA damage and sensitizes cells to PARP inhibitors.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

The paper presents cryo-EM structures of the human calcium-sensing receptor in inactive and active states, revealing structural changes during activation.

The paper isolates and characterizes cross-neutralizing antibodies from COVID-19 patients, identifying antibodies that neutralize both SARS-CoV-1 and SARS-CoV-2, including variants.