L. Zhu

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

This paper introduces self-confocal NIR-II fluorescence microscopy systems for in vivo imaging, improving adjustability and enabling cerebrovascular and hepatic imaging.

This study shows that primary cilia in pancreatic beta cells move and this movement is essential for glucose-dependent insulin secretion.

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

This study constructs a lux-based promoter-reporter system to screen small-molecule compounds for anti-TB activity, identifying one antibiotic and two anti-virulence agents.

This study shows garlic-derived organosulfur compounds reduce inflammation in macrophages and intestinal epithelial cells, and alter gene expression during intestinal infection in mice.

This study shows that cGAS-STING signaling in cancer cells promotes drug resistance by responding to cytosolic DNA from chemotherapy, suggesting caution in combining STING agonists with chemotherapy.

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

The paper investigates how ESCRT-0 and ubiquitinated cargo are recruited and organized via condensation at yeast vacuoles, showing multivalent interactions drive substrate recognition.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

This study examines the effects of imidacloprid and thiamethoxam at LC30 and LC50 concentrations on the life table parameters of soybean aphid, showing significant changes in reproduction and development rates.

This study shows that cinnamaldehyde reduces intestinal inflammation and improves resistance to enteric parasite infection in mice, independent of gut microbiota.

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

This paper describes an AAV-mediated in vivo CAR gene therapy that generates CAR T cells within the host, leading to tumor regression in a humanized mouse model.

This paper introduces a deep learning method to improve light-field microscopy, enabling high-speed, artifact-free volumetric imaging of biological processes.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.

This study investigates TAK1's role in retinal neovascularization and shows that inhibiting TAK1 reduces aberrant angiogenesis in a rat model.

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

This study identifies an autoregulatory negative feedback loop involving PIF4 and HECs that modulates thermomorphogenesis in Arabidopsis in response to high ambient temperature.

This study shows ESR1 mutant breast cancers exhibit basal cytokeratin expression and immune activation, linked to chromatin reprogramming and paracrine signaling.

This study investigates the tumor-suppressing functions of hsa-miR-654-5p in lung cancer through bioinformatic analysis and in vitro experiments, revealing its role in inhibiting EMT, proliferation, and migration.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This paper proposes a spiking neural network model of the mushroom body to encode spatio-temporal visual memory for insect navigation, showing it can distinguish learned from unlearned routes with noise tolerance.

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This paper improves ELISPOT assay sensitivity for detecting neoantigen-specific T cells by co-stimulating with anti-CD28 and IL-2, increasing detection by up to 5-fold.

The paper identifies novel alternative splicing events in early-onset gastric cancer and links them to protein modification and immune microenvironment changes.