L. Zhu

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

SiCTeC enables rapid, precise temperature shifts for single-cell imaging, revealing cellular responses to temperature changes in E. coli.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

The paper reveals the structure and composition of the mouse axonemal radial spoke head using cryo-EM, showing distinct subunit composition and organization compared to Chlamydomonas.

This study shows that heterotypic interactions drive nucleolar phase separation without a fixed saturation concentration, revealing a thermodynamic framework for condensate composition and function.

The paper examines genetic variation in the Spy1336/R28 and Spy1337 virulence genes of S. pyogenes and its effects on transcript levels and virulence in infection models.

This paper demonstrates that CRISPR-Cas9-assisted native end-joining editing can efficiently knock out large genomic regions in E. coli without exogenous repair systems.

This study demonstrates the use of modified LCP and MicroED protocols to determine structures from microcrystals embedded in LCP using proteinase K as a model system.

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

This study evaluates genomic selection effectiveness for winter wheat improvement by assessing prediction accuracy and response to selection across different environmental conditions.

The paper compares immune cell infiltration in primary and metastatic breast tumors, finding reduced immune cell abundance but increased M2-like macrophages in metastases.

This study identifies GAS genes critical for necrotizing myositis in nonhuman primates using TraDIS, highlighting transporter genes as key contributors to pathogenesis.

This study identifies KDM4D as a key regulator of hepatic fibrosis by modulating TLR4 signaling through histone demethylation in HSCs.

This study shows that an early nitric oxide burst mediated by nitric oxide synthase in ammonium-supplied rice roots reduces drought-induced oxidative damage by enhancing antioxidant defenses.

This study shows that Pseudomonas aeruginosa supernatants, containing rhamnolipids, effectively disperse biofilms of sulfate-reducing bacteria and other microbes.

This study replicates MERS and SARS coronaviruses in bat cells, finding that DPP4 expression and species-specific factors determine viral susceptibility.

This study maps intracellular phase separation behavior using an optogenetic system, showing localized phase separation can occur through diffusive capture of protein ligands.

The paper identifies an arabinopyranosyltransferase from Physcomitrella patens involved in xyloglucan synthesis and shows its role in restoring plant growth in mutants.

This study identifies 92 Streptococcus pyogenes genes essential for fitness in human saliva using a transposon mutant screen, highlighting roles in nutrient transport and metabolism.

This paper uses persistent homology to analyze leaf shapes from 182,707 leaves across 141 plant families, revealing phylogenetic and geographic differences in leaf morphology.