P. Zou

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 Diabetes Mellitus Rats

This study shows that Grifola frondosa polysaccharide reduces inflammation and insulin resistance in T2DM rats by modulating liver macrophage polarization.

Gentle rhodamines for live-cell fluorescence microscopy

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

A novel simian adenovirus vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

Predicting Human Bioavailability of Subcutaneously Administered Fusion Proteins and Monoclonal Antibodies

This study predicts human subcutaneous bioavailability of fusion proteins and monoclonal antibodies using physicochemical and pharmacokinetic properties with multivariate regression models.

Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome

The paper introduces a method to label and profile subcellular proteins in living cells using a genetically encoded photocatalyst and reactive probes, achieving high specificity in mitochondrial proteome analysis.

First-in-patient dose prediction for adeno-associated virus-mediated hemophilia gene therapy using allometric scaling

The paper compares allometric scaling and body weight-based methods for predicting first-in-patient doses in AAV-mediated hemophilia gene therapy using preclinical and clinical data.

A Genetically Encoded Fluorescent Sensor Enables Real-time Detection of the Intracellular GTP:GDP Ratio

This paper introduces GNEPS, a fluorescent sensor that detects intracellular GTP:GDP ratios in real-time, showing its utility in monitoring metabolic changes across cell types and organelles.

Exponential Growth of Glioblastoma In Vivo Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

This study identifies that glioblastoma grows exponentially due to symmetric divisions of brain tumor stem cells (BTSCs) accumulating at the tumor rim.

Ex vivo dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypes

This study uses a microvasculature-on-a-chip system to analyze ex vivo dynamics of human glioblastoma cells, showing correlations with tumor heterogeneity and subtypes.