S. Lin

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

The paper identifies an AP-3-dependent pathway in yeast leading to vacuole membrane permeabilization and cell death, conserved in Cryptococcus neoformans.

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

This paper develops a BSL2 pseudovirus neutralization assay to assess SARS-CoV-2 variant neutralization, showing it is reproducible and effective for evaluating vaccine efficacy against emerging variants.

The paper analyzes meiosis in Pristionchus pacificus, showing that DMC-1 and RAD-51 have distinct roles in homolog pairing and synapsis compared to C. elegans.

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

This study shows that calorie restriction and rapamycin have distinct and additive effects on aging skeletal muscle gene expression and function in mice.

The paper investigates the roles of EGFR ligands in ERK activation waves during MDCK cell migration, finding redundancy and specific contributions among the ligands.

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

This study identifies novel therapeutic targets for AML using an in vivo CRISPR screening platform, revealing SLC5A3 as a metabolic vulnerability and MARCH5 as an apoptosis regulator.

The paper analyzes T-cell infiltration in colorectal cancer, identifying prognostic and non-prognostic T cell subtypes and their clinical implications.

The paper reports the cryo-EM structure of human NALCN with FAM155A, revealing interactions and ion-binding sites that inform Na+ permeation and disease mechanisms.

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

This study identifies X-206, a polyether ionophore antibiotic, as a potent and selective inhibitor of SARS-CoV-2 infection in vitro with high selectivity and sub-nM efficacy.

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

This study examines how Fugacium kawagutii responds to nitrogen deficiency and different nitrogen forms, finding ammonium is preferentially used and identifying stable reference genes for future studies.

This study shows that the LINC complex transmits integrin-generated tension to the nuclear lamina, repressing epidermal differentiation in stem cells.

The paper identifies a 22-gene expression signature to measure glycolysis activity across 25 cancer types, showing its correlation with hypoxia, genomic instability, and tumor proliferation.

The paper investigates exosome-mediated apoptosis during WSSV infection in mud crabs, identifying miR-137 and miR-7847 as negative regulators of apoptosis by targeting AIF.

This study evaluates the binding of ritonavir, lopinavir, and darunavir to SARS-CoV-2 proteases using molecular modeling, finding that ritonavir and lopinavir inhibit CEP_C30 more effectively than darunavir inhibits PLVP.

The paper identifies phosphorylation of H3.3S31 in response to pathogen sensing in macrophages and shows its role in recruiting SETD2 to enhance transcription of inflammatory genes.

The paper isolates and characterizes a Rhizobium bacterium associated with the dinoflagellate Gambierdiscus balechii, showing it benefits from the association by utilizing extracellular organic matter.

This study shows RNF168 ubiquitin ligase is required for SET8 methyltransferase recruitment to DNA damage sites, suggesting a coordinated mechanism for DDR signaling.

The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.

This study shows that the SIK3 inhibitor YKL-05-099 suppresses MEF2C function and slows AML progression in mouse models.

This paper develops a tissue clearing coupled with light sheet fluorescence microscopy method to image coral holobionts at single-cell resolution, revealing endosymbiont distribution and physiological dynamics.

This study investigates transcriptomic responses of Symbiodinium kawagutii to thermal stress, phosphate deprivation, and glycerol-3-phosphate replacement, identifying core genes and differentially expressed genes across conditions.

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.