W. Jiang

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

This paper identifies that NS5A of CSFV inhibits NF-κB signaling by degrading NEMO and blocking its k63-linked polyubiquitination.

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

This study shows that PIEZO1 channels exhibit cooperative behavior under mechanical stress, enhancing their sensitivity to small tension changes through inter-channel interactions.

The paper uses molecular dynamics simulations to study Piezo1 channel opening and identifies a multi-fenestrated ion permeation pathway.

This study investigates the free energy and kinetics of cAMP permeation through connexin26 hemichannels using simulations, revealing binding sites, directional transition rates, and the role of voltage and ions.

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

This study investigates how female sex hormones, specifically estrogens, may protect against SARS-CoV-2 infection by disrupting glycan interactions involved in viral entry.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

This paper develops an endogenous quorum-sensing based CRISPRi circuit (EQCi) to dynamically regulate multiple targets in Streptomyces, achieving higher rapamycin titers without affecting cell growth.

The paper develops and validates a high-fidelity 3D continuum model for avian voiced sound production, showing it accurately predicts vibratory and acoustic traits.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

This study establishes an in vitro model of HAV/HCV coinfection and finds mild reciprocal viral interference due to competition for rNTPs in RNA synthesis, suggesting indirect interactions explain HCV suppression in coinfected patients.

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

This study identifies sr8384, a novel small noncoding RNA in Clostridium acetobutylicum, which regulates growth and solvent synthesis, and shows its functional conservation in another clostridial species.

The paper identifies genetic regulators and signaling pathways involved in bulbil outgrowth in Dioscorea alata using transcriptomic and morphological analyses.

This study combines Azospirillum brasilense inoculation with seed priming to enhance germination and seedling growth in aged grass seeds, finding that H2O2 priming with optimal bacterial concentration and time is most effective.

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

This study applies MBIR to cryo-ET data to reduce missing wedge artifacts and improve resolution, showing its potential for high-resolution biological structure determination.

This paper introduces EVER, a method to improve super-resolution microscopy by recovering distorted emitters in heterogeneous backgrounds, enhancing image quality without manual parameter adjustment.

This study shows that astigmatism in TEM images changes with defocus and magnification, invalidating assumptions about its invariance and suggesting better alignment practices.