X. Lin

This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.

This paper isolates and characterizes a quinclorac-degrading bacterium, Cellulosimicrobium cellulans sp., showing 45.9% degradation efficiency and identifying two novel degradation products.

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This paper introduces ELViM, a reaction coordinate-free method to analyze energy landscapes of IDPs, revealing conformational differences between phosphoforms of PAGE4.

This study compares steroid activation of elephant shark and human progesterone receptors, revealing evolutionary changes in specificity and response to RU486.

This study investigates the stability and folding pathways of a tetra-nucleosome using a near-atomistic model and deep learning, revealing the zigzag structure as a global minimum but not the dominant configuration.

This paper describes two new species of Faecalibacterium isolated from human feces, supported by phylogenetic, genomic, and phenotypic analyses.

This study uses atomic packing frustration analysis to refine predicted protein structures, improving their quality through guided simulations.

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

This paper describes a new bacterial species, Christensenella intestinihominis, isolated from the human gut, and reports its cholesterol-lowering ability and exopolysaccharide production.

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

The paper develops SARS-CoV-2 vaccine candidates by displaying the receptor-binding domain and a stabilized spike on self-assembling protein nanoparticles, showing enhanced neutralizing antibody and T-cell responses.

The paper describes the isolation and characterization of a new butyric acid-producing bacterium from human feces, and reclassifies another species within the same family.

This study designs and tests Ebola virus vaccines using stabilized GP trimers displayed on nanoparticles, showing they induce neutralizing antibodies and enhance infection.

The paper shows that the N-terminal domain of elephant shark GR regulates steroid activation, with functional divergence from MR.

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

The paper identifies a new R gene, Rpi-amr1, from Solanum americanum that provides broad-spectrum resistance to Phytophthora infestans and defines its allelic diversity.

This paper presents an HCV vaccine strategy using redesigned E2 cores displayed on nanoparticles to elicit broadly neutralizing B-cell responses.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This paper introduces RACER, a pairwise energy model that assesses TCR-peptide affinity using supervised machine learning, demonstrating its utility in simulating thymic selection and estimating recognition rates for tumor antigens.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This paper develops a CRISPR-Cas13-based strategy called PAC-MAN to inhibit SARS-CoV-2 and influenza A virus in human cells, showing it can degrade viral sequences and reduce replication.

This paper introduces RLP/KSeq, a method to rapidly map receptor-like protein (RLP) and receptor-like kinase (RLK) genes in plants, demonstrating its application in identifying PRRs in Solanum species.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

The paper measures dissolved oxygen dynamics in a hydropeaked river system to identify hydrobiogeochemical tipping points driven by rapid hydrologic changes.