X. Liu

This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.

This study uses vis-OCTF and TSA to image tree shrew retinal ganglion cell axon bundles in vivo, quantifying their dimensions and showing changes with distance from the optic nerve head.

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

This study identifies a PilO homolog in H. pylori that enhances soft-agar migration when cheV1 is deleted, suggesting a role in chemotaxis and motility regulation.

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

This study shows Bacillus subtilis adapts genetically to different plant hosts and alternating host regimes, revealing both parallel and species-specific evolutionary patterns.

This study compares single-species and microbial consortium inoculation effects on biofertilization and bioremediation in soil, finding consortia more effective in field settings.

The paper investigates how membrane tension affects the size, lifetime, and spatial distribution of clathrin-coated pits during maturation.

This study shows that di-n-butyl phthalate exposure reduces ovarian IGF1 system components and disrupts folliculogenesis in mice.

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

This study investigates the role of ALOX15 in lung adenocarcinoma, finding that its downregulation correlates with tumor differentiation, proliferation, and metastasis, and that overexpression inhibits cancer cell growth.

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

This study shows that the type VI secretion system in Geobacter metallireducens affects DIET by altering gene expression and electron transfer efficiency.

The paper examines mitogenomic evolutionary rates in Bilateria, finding that parasitism and reduced locomotory capacity are associated with elevated rates, explaining a significant portion of variance in branch lengths.

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

This study identifies RIPK3-dependent necroptosis as the main cause of immunodeficiency in RIPK1-deficient rats and suggests necroptosis inhibition as a potential therapy.

The paper identifies palmitoylation of GSDMD at Cys191/Cys192 as essential for its membrane translocation and pore-forming activity in macrophages.

This study shows that extra-islet antigen exposure leads to T-cell exhaustion, which prevents autoimmune diabetes in NOD mice.

This study identifies a comprehensive allergen profile of Blomia tropicalis and validates novel allergens for component-resolved diagnosis of mite allergy.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.