X. Liu

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

This study identifies the role of positively charged residues in helper NLRs for phospholipid binding and plasma membrane association, and shows effector activation induces NRG1 oligomerization at the plasma membrane.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

This paper develops a mathematical model explaining the evolution of parthenogen fertilization rates and reproductive modes through coevolution of fertilization rate and cell size.

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

This paper introduces a new plant transformation method called RAPID that achieves high efficiency and speed without tissue culture.

This paper describes a novel oncolytic virus encoding a bispecific T-cell engager targeting CEACAM6-expressing tumors, showing enhanced anti-tumor efficacy and safety in vitro and in vivo.

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

This study identifies TACAN as a PKD2 inhibitor that modulates its channel activity and mechano sensitivity in renal cells and zebrafish.

The paper uses genome and transcriptome data to resolve the phylogeny of chitons, supporting that shell eyes originated in Schizochitonoidea and evolved secondarily in other genera.

The paper sequenced waterbuck genomes to study speciation, finding historical gene flow across a Rift Valley barrier and no reproductive isolation.

This study compares mutational spectra in biofilms of two Bacillus species under abiotic and biotic conditions, finding that smaller population sizes and biotic environments lead to higher mutation rates and diversity.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The paper improves a centrality algorithm by incorporating protein properties and validates it using yeast networks to study the hepatotoxicity of Pinelliae Rhizoma.

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

This study uses a computational model to show that ventricular systolic function affects thrombus formation after EVAR, with specific correlations identified.

The paper analyzes metagenomic and metatranscriptomic data from cold seeps to identify As-cycling genes and microbes, revealing unexpected diversity and functional roles in arsenic transformation.

This paper develops mRNA vaccines against Monkeypox virus that protect mice from lethal infection, with fusion protein vaccines showing better immune responses than separate protein vaccines.

This paper develops a kinetic model for solid waste treatment units using system dynamics and simulation, demonstrating its validity through a 370-day experiment with a prototype.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

The paper identifies divergent electrophile-signaling behaviors between zebrafish Keap1 paralogs using Z-REX, showing zKeap1b promotes Nrf2 signaling while zKeap1a inhibits it.