X. Wu

This study uses whole exome sequencing to track cervical cancer mutations during chemoradiation, finding that CDK4/CDK6/cyclin D1-related mutations persist or increase, suggesting radiation resistance.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.

This study examines cannabinoid-related gene expression in disease cell lines, finding differences between normal and cancerous cells and across tissue origins, suggesting potential therapeutic applications for phytocannabinoids.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.

This study shows that PUFA analogues differentially modulate cardiac ion channels through distinct mechanisms, suggesting potential tailored therapies for specific LQTS mutations.

The paper identifies four humoral immune factors in Biomphalaria glabrata that coordinate to mediate resistance to Schistosoma mansoni infection.

The paper shows MSI-1 and EXC-7 regulate serotonin-mediated mating behaviors in C. elegans by stabilizing mRNA of a G protein and affecting serotonin synthase activity.

This study identifies SidJ as a bacterial pseudokinase that catalyzes polyglutamylation of SdeA, a Legionella effector, in a CaM-dependent manner, suppressing ADP-ribosylation.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.

The paper shows that Arp2/3 complex-driven spatial reorganization of BCR microclusters enhances immune synapse formation, BCR signaling, and B cell activation in response to membrane-bound antigens.

This study identifies IL17 and senescence as regulators of the foreign body response, showing their roles in fibrosis and potential as therapeutic targets.

The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.

The paper describes a modified TCA/acetone precipitation method for plant protein extraction that is faster and reduces protein degradation compared to traditional methods.

The paper identifies NSAPP as an oxide transport chain regulated by NADPH oxidase-4 that modulates insulin signaling by inactivating PTEN through H2O2 transport.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

This study shows exogenous putrescine increases cyclic electron flow in cucumber under salt stress, improving ATP/NADPH ratios and reducing photoinhibition.

The paper screens SaCas9 specificity using a barcoded pairwise library of sgRNAs and identifies optimal spacer lengths for off-target activity.

This paper demonstrates the use of polymer dots for deep in vivo multiphoton imaging in mice, showing improved signal-to-background ratio and imaging depth.

COREMIC identifies core microbiomes associated with habitats by analyzing databases, demonstrating its ability to find consistent microbial taxa across diverse environments.

This study shows that RAF1 mutations in Noonan syndrome cause cardiac hypertrophy through cytokine signaling from endothelial cells, with TNF/IL6 as potential therapeutic targets.

This study demonstrates that Cpf1 nucleases from Francisella novicida and Lachnospiraceae bacterium ND2006 can efficiently insert genes into the rice genome via homology directed repair.