X. Wu

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

This study identifies early emergence and long-term persistence of HIV-infected T cell clones in children on antiretroviral therapy, with proviral integration in proto-oncogenes.

This study evaluates Nanopore sequencing for differentiating Salmonella serotypes and variants with similar antigenic formulas using SNP analysis and prophage prediction.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

The paper shows that tumors can have multiple clonal origins, leading to high functional heterogeneity, with some tumors containing 13 independent clones and others having a dominant clone with minor patches.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

The paper examines ORC/MCM density in relation to replication timing and initiation zones, finding no direct correlation with initiation but a link to replication timing.

This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.

This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

This study compares 16S rRNA and whole-metagenome sequencing in cervical cancer patients, finding congruence in diversity metrics but discrepancies in genus-level abundances.

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

This study tracks gut microbiome diversity and composition changes in gynecologic cancer patients undergoing chemoradiotherapy, finding reduced diversity during treatment but partial recovery by week 12.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study reports cryo-EM structures of a P4-ATPase lipid flippase in lipid bilayers, revealing mechanisms of lipid transport and ATP coupling.

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

This study identifies multi-genetic mechanisms of metronidazole resistance in C. difficile, showing epistasis between iron homeostasis and oxidoreductases.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

This study identifies Myosin-7B and SLC35B2 as critical regulators of α-Synuclein fibril endocytosis, revealing a distinct pathway involving HSPG interactions and actin dynamics.

This study evaluates drug inhibitory effects on Babesia parasite growth using real-time PCR with 18S rRNA quantification and shows significant gene expression reduction after drug treatment.

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

This study demonstrates that cross-feeding between Thauera aminoaromatica and Rhodococcus pyridinivorans drives quinoline degradation in a denitrifying bioreactor through 2-hydroxyquinoline as an intermediate.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

This study identifies ZBED2 as a transcriptional repressor that antagonizes IRF1 to modulate cell identity and suppress interferon response in pancreatic cancer.