X. Zhang

This paper develops an in-silico labeling method using a generative adversarial network to predict fluorescent images from brightfield images, enabling kinetic myelination assays.

This study uses multiphoton microscopy to examine blood vessel dynamics and oxygen metabolism during cranial bone defect repair, revealing differential metabolic responses between endothelial cells and osteoblasts.

This study uses single-cell RNA sequencing to show that aging impairs intestinal stem cell maturation, which is reversed by metformin and rapamycin.

This study shows that CNTNAP4 signaling promotes osteosarcoma progression, and its deletion reduces tumor growth, angiogenesis, and metastasis.

The paper shows that within-host adaptation changes priority effects in the phyllosphere microbiome by altering ecological interactions and host impact.

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

The paper introduces ELI-TriScope, a cryogenic system for precise cryo-lamella preparation, achieving 100% success in targeting HeLa cell centrosomes for cryo-ET structural analysis.

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.

RapidAIM 2.0 evaluates gut microbiome functional responses to xenobiotics using high-throughput metaproteomics and in vitro culturing.

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

This paper uses a 3D human atrial myocyte model to study how changes in Ca2+-handling proteins and TATS density affect arrhythmia mechanisms in disease.

This study develops a 3D human atrial myocyte model to investigate how variations in transverse-axial tubule systems (TATS) affect Ca2+ handling and promote arrhythmia through spontaneous Ca2+ release.

This study identifies NCgl0254 and NCgl0255 as novel O_SCPLOWLC_SCPLOW-serine exporters in C. glutamicum and shows that all four exporters (ThrE, SerE, NCgl0254, NCgl0255) are interdependent in O_SCPLOWLC_SCPLOW-serine export, with SerE being the major contributor.

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

This study shows metformin lowers IOP and protects trabecular meshwork from oxidative damage by activating integrin/ROCK signaling in both in vivo and in vitro models.

This study shows that tumor-educated monocytes suppress T cells via adenosine and that depleting adenosine with PEG-ADA enhances immunotherapy response in preclinical models.

This study identifies RHAMM as a marker of invasive niches in breast cancer, showing its association with poor outcomes and promoting invasion through a 27-gene signature.

The paper identifies a regulatory mechanism linking drought stress and fiber yield in upland cotton through the interaction of GhHSFA6B-D and GhIPS1-A, showing conservation in Arabidopsis.

This study investigates the adhesion of SARS-CoV-2 S proteins from different variants to human ACE2 using single-molecule and single-cell force spectroscopy, finding Delta variant has the highest binding affinity.

This study shows that ZF-tMeCP2, a cell-penetrant MeCP2 variant, can deliver to the nucleus and repress transcription from methylated promoters, suggesting a potential therapeutic strategy for Rett syndrome.

The paper develops bacterial Vm sensors to study Vm dynamics and shows that excitable states enhance antibiotic tolerance.

The paper shows that plant defense elicitors induce amino acid accumulation, which directly suppresses bacterial virulence and growth.

This paper develops an automated machine learning pipeline for differential cell counts on whole-slide bone marrow aspirate smears, showing high concordance with manual counts and reduced intra-slide variance.

This study identifies a cooperative interaction between HAND2 and MYCN in neuroblastoma that regulates enhancer binding and gene transcription, and shows that targeting these factors suppresses tumor growth.

This study demonstrates that nuclear sAC-mediated cAMP synthesis is necessary and sufficient for cAMP-dependent cell proliferation, independent of cytosolic cAMP levels.

MaLAdapt identifies novel adaptive introgression loci from Neanderthals and Denisovans in non-African populations using machine learning.

The paper uses proximity labeling and proteomics to identify proteins interacting with emerin and LBR at the inner nuclear membrane, revealing shared and distinct partners.

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.