X. Zhang

This study investigates the structural and functional roles of Zn2+/H+ antiport in YiiP using cryo-EM, thermophoresis, and simulations, revealing a transport stoichiometry of 1 Zn2+ to 2-3 H+.

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

This study identifies miR-193a-5p as a regulator of vascular smooth muscle cell proliferation and migration in aortic aneurysms, showing that RelB represses its expression.

The paper identifies novel transmembrane proteins enriched at the nuclear envelope using proteomics and validates their localization and function.

The paper identifies over 6,000 transcription factor binding sites (TFBSs) under accelerated evolution in primates, suggesting their role in neurodevelopmental divergence.

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

The paper shows engineered symbiotic bacteria can inhibit microsporidia infection in honeybees by delivering RNAi targeting the parasite's redox system.

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

This study shows that aged bone marrow-derived cells increase smooth muscle cell polyclonality in atherosclerotic plaques through reduced TET2 and increased TNF signaling.

This paper identifies and characterizes the gene PLATZ-A1 underlying the GA-sensitive dwarfing locus RHT25 in wheat, showing it interacts with RHT1 and can modulate plant height.

This study shows that SARS-CoV-2 NSP2 enhances miRNA-mediated translational repression by interacting with Argonaute 2 and the GIGYF2 complex.

This paper shows that phosphorylation enhances Mec1-Ddc2 recruitment to RPA-ssDNA, facilitating DNA damage checkpoint signaling in yeast.

The paper identifies paired NLRs in Solanaceae species and shows their coordinated role in modulating NRC3-mediated ETI to enhance age-dependent immunity.

This paper conducts a bibliometric analysis of cancer alternative splicing research from 2012 to 2021, identifying trends, key institutions, and research areas.

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

This paper develops genetically immortalized bovine satellite cells for cultured meat production, achieving over 120 doublings while maintaining myogenic differentiation capacity.

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.

This study identifies MDF as a splicing factor regulating root meristem function in Arabidopsis by controlling splicing of RSZ33, ACC1, and SR34, balancing stemness and stress response.

This study identifies distinct dopamine neuron functions in Drosophila that drive attraction and aversion during olfactory memory formation, showing separate roles for dopamine, glutamate, and octopamine.

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

The paper measures the bending stiffness of the bacterial flagellar hook under counterclockwise and clockwise rotations, finding it doubles under clockwise rotation.

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

This study shows PSKR1 in Arabidopsis balances growth and defense responses to maintain beneficial rhizosphere microbiome interactions.