Y. Chen

This study shows that flagellum malfunctions in Euglena gracilis trigger metaboly, an escape strategy used to avoid restrictions and restore flagellar function.

This study combines mechanistic and machine learning models to optimize tryptophan metabolism in yeast, achieving a 106% increase in tryptophan accumulation through predictive engineering.

The paper identifies endogenous foamy viruses in two stork species, showing independent integration events in birds and expanding the known taxonomic distribution of foamy viruses.

This paper uses UAS to model maize growth and identifies temporal QTL associated with plant height, showing dynamic expression patterns over time.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.

This study traces the evolutionary origin of the Hippo pathway from unicellular ancestors and examines its oncogenic alterations in mammals.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This paper investigates the structural mechanism of regioselectivity in a bacterial acyl-CoA dehydrogenase, identifying key residues and structural features responsible for its unique substrate specificity.

The paper identifies a small molecule cocktail, CEPT, that enhances the viability and cytoprotection of human pluripotent and differentiated cells through multi-target drug combinations.

This study identifies HOTTIP's role in promoting pancreatic ductal adenocarcinoma through both canonical HOXA13-mediated and non-canonical WDR5-MLL1-H3K4me3 pathways.

The paper identifies a positive feedback loop involving CDK9, histone modification, and DNA methylation that enhances HOTAIR expression through transcription elongation in cancer.

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

The paper shows that UBP12 and UBP13 deubiquitinate DA1, DAR1, and DAR2, reducing their activity and affecting plant growth and development.

This study investigates the population dynamics of Deformed wing virus (DWV) in honey bees, finding high genetic diversity in US colonies and proposing a model of diversification driven by negative frequency-dependent selection.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This study identifies circFOXK2 as an oncogenic circRNA in PDAC that promotes tumor growth and metastasis by acting as a miR-942 sponge and interacting with RNA-binding proteins.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

This study evaluates two tDCS optimization schemes for single and multi-target brain stimulation, showing that parameter settings significantly affect outcomes, especially in multi-target cases, and proposes improved weighted schemes.

This paper shows that Pseudomonas putida can grow on lignolysate from sorghum, using aromatic monomers and other unknown factors like amino acids and ionic liquid.

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

This study demonstrates that self-homing circulating tumor cells can target and treat metastatic breast cancer using gene therapy and bioluminescence imaging.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

The paper was withdrawn due to lack of full author consent and is not intended for citation.

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.

The paper develops a light-driven population model to examine how light-dependent life history traits of Prochlorococcus and cyanophage influence population dynamics, finding that light-dependent adsorption improves model fits but lysis saturation at high virus-to-cell ratios also plays a key role.

This study identifies Rap1a as a conserved regulator of glioblastoma cancer stem cell migration using a combination of Drosophila and human models.