Y. Fu

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

This study shows that Toxoplasma bradyzoites have reduced calcium and energy stores, limiting their motility and egress, but they can rapidly restore these stores upon release from cysts.

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

Librator is a platform for sequence editing and design of influenza virus proteins, enabling efficient mutation and chimeric protein creation for vaccine development.

The paper develops a continuum membrane model to predict how helix insertion affects curvature sensing in membranes, showing it lowers energy for small vesicles but destabilizes larger ones.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study shows that young and undamaged recombinant mouse serum albumin (rMSA) extends the lifespan and healthspan of C57BL/6N mice by 17.6% and 20.3% respectively.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

This study describes a 370-day closed artificial ecosystem experiment to test bioregenerative life support systems for long-term lunar habitation, demonstrating high material closure and system stability.

This study identifies ICR2 and its homologs as regulators of ROP signaling and microtubule dynamics in Arabidopsis.

This study identifies JAM2 as a prognostic marker and potential predictor of immunotherapy response in breast cancer using multi-database analysis.

This study uses a novel mouse model to show that spontaneous metastases in synchronous bilateral breast cancer originate from both primary tumors, revealing high cross-seeding of metastatic cells.

This study evaluates the efficacy of STI-2020 antibody delivered post-infection via intranasal or intravenous routes in a hamster model of COVID-19, showing reduced disease severity and duration.

This study examines how a controlled closed environment affects human saliva microbiota and cytokines, finding stable microbial communities and reduced inflammatory markers.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

The paper investigates how synergistic epistasis enhances cooperativity in mutualistic interspecies interactions between Desulfovibrio vulgaris and Methanococcus maripaludis under varying sulfate conditions.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

The study examines dominance hierarchies among female Yunnan snub-nosed monkeys using aggressive-submissive behaviors and grooming reciprocity, finding loose hierarchies and higher grooming income for dominant individuals.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

NERDSS simulates multibody self-assembly processes by integrating reaction-diffusion with rule-based models, enabling comparison with experimental data on clathrin-mediated endocytosis and viral lattice assembly.

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

This paper introduces an implicit lipid model for efficient reaction-diffusion simulations of protein binding to surfaces of arbitrary topology, showing agreement with explicit lipid models and enabling stable multi-protein complex formation.