Y. Su

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

This study shows that Tmem138 is essential for rhodopsin transport across the photoreceptor connecting cilium and outer segment biogenesis, with its absence causing photoreceptor degeneration.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

The paper maps the central and peripheral projections of lung-innervating sensory neurons, identifying their targets and marker expression.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This study identifies ALPPL2 as a tumor-specific antigen and demonstrates that synNotch CAR T cells targeting it improve tumor control by reducing T cell exhaustion.

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

The paper screens a transposon mutant library in Staphylococcus aureus to identify genes enhancing transduction by phage φ11, revealing both lateral and specialized transduction mechanisms.

This paper introduces a polymer gel matched to water's refractive index, enabling high-resolution imaging of living cells and organisms in thick layers.

This study develops a BSL-2-compatible system using SARS-CoV-2 virus-like particles to model viral budding and entry mechanisms and assess drug inhibitors.

The paper designs a new class of protease inhibitors targeting coronavirus Mpro, identifying ML1000 as a potent inhibitor with low-nanomolar affinity and antiviral activity.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

This paper shows β-chitosan blocks SARS-CoV-2 S-RBD binding to ACE2 and reduces inflammation, acting like an antibody and modulating ACE2 cleavage.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

The paper identifies four metabolites that reduce Staphylococcus aureus bloodstream infection by inhibiting arginase and enhancing phagocytic killing through a nitric oxide-dependent mechanism.

The paper identifies ALPPL2 as a highly specific tumor cell surface antigen for mesothelioma and demonstrates its therapeutic potential through an antibody-drug conjugate.

This study introduces a modular method to generate bispecific and multi-specific antibodies using temporary linkers and proteases, enabling efficient production with desired properties.

The paper shows STAT3 localizes in mitochondria-associated ER membranes, not mitochondria, and other mitochondrial TFs also localize to MAMs.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

This paper introduces faster deconvolution and multiview fusion methods, achieving speedups of 10 to several thousand-fold over previous approaches.

This study identifies novel and validated QTLs for fiber quality traits in Upland cotton using a paternal backcross population and RILs, with some QTLs explaining over 10% of phenotypic variation.

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.