Y. Xia

This paper shows that synonymous mutations alter enzyme function over time by causing misfolded, entangled protein states that reduce catalytic activity.

The paper identifies Rhodanese 2 (Rdl2) as critical for protecting mitochondria from hydroxyl radical damage in yeast by converting sulfur species into reactive sulfane sulfur.

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

This study shows that microbiome dysbiosis in ALS mice precedes motor neuron degeneration and affects intestinal neuromuscular function, with interventions improving symptoms.

This paper introduces a method to screen early human embryos for genetic variants using primary template-directed amplification, identifying aneuploidy, mitochondrial variants, and disease-causing mutations, and computing polygenic risk scores.

This study links VDR regulation of Claudin-5 to intestinal barrier function and tumorigenesis in colorectal cancer, showing VDR deficiency reduces Claudin-5 and increases tumor formation.

The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

This study shows that the hydrophobin HYD3 from the specialist fungal pathogen Metarhizium acridum activates immunity in its host locust but not in non-host insects.

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

The paper quantifies evolutionary importance of protein sites using two measures and finds a strong linear relationship between them, with catalytic sites being an exception.

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

The paper identifies a subset of exhausted CD8 T cells with plasticity to reprogram into memory cells, suggesting new targets for immunotherapy.

This study shows that intestinal VDR protects against dysbiosis and tumorigenesis by modulating the JAK/STAT pathway through microbiome interactions.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

The paper analyzes bacterial diversity succession in compost made from pig manure and wood chips using 16S rRNA gene analysis, showing shifts in microbial phyla over composting stages.

This study investigates how hyperthermia induces neural stem cell differentiation and shows that HSP90 regulates this process through the HIF-1 pathway.

The paper shows that catalytic sites in enzymes induce stronger evolutionary rate gradients than non-catalytic binding sites, suggesting catalytic optimization drives these gradients.

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

The paper investigates DNA damage and cell cycle effects during constricted cell migration, finding a bimodal relationship between DNA damage and cell cycle regulation.