Y. Xu

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

The paper investigates how protein conformational heterogeneity contributes to NMR lineshape broadening at cryogenic temperatures by analyzing backbone torsion angles in E. coli DHFR.

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

This study shows that combining RBM39 degraders with PARP inhibitors improves PARP inhibitor response in ovarian cancer, regardless of BRCA1/2 status.

This study uses scRNA-seq to create a single-cell atlas of murine reproductive tissues during infection-induced preterm labor, identifying gene expression signatures and intercellular communication changes.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.

This study quantifies spatial heterogeneities in membrane crowding on live cells using antibody binding, revealing sharp gradients near crowded regions and supporting raft-like domain exclusion of large proteins.

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

This study identifies tumor-specific CD4 T cells as regulators of monocyte differentiation into antitumor macrophages in pancreatic ductal adenocarcinoma, showing their role in suppressing tumor growth.

The paper presents cryo-EM structures of bombesin receptors bound to their neuropeptide ligands, revealing the mechanism of ligand selectivity and receptor activation for itch treatment.

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

This study identifies the N-terminal extension of Arabidopsis AGO1 as essential for miRNA activity, showing its role in miRNA loading and trans-acting siRNA biogenesis.

This study identifies PBX1 as a critical regulator of LAM progression by analyzing scRNA-seq data and validating its role in LAM cell survival and lung colonization.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

This paper develops an ABC method to infer selection strength and number of selected SNPs from experimental evolution data, accounting for genomic linkage effects.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

This study uses an agent-based model to show that habitat loss in migratory waterfowl flyways can shift AIV outbreaks northward, increase outbreak risk, and enhance transmission among geese.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.