Y. Yu

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

This study identifies 2,119 proteins and 2,950 phosphosites in sepsis-induced kidney injury, revealing pathways related to metabolism, oxidative stress, and energy consumption during transition to chronic kidney disease.

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

This study characterizes the molecular composition of neutrophil extracellular traps (NETs) using omics approaches, revealing specific genomic and proteomic signatures.

This study investigates how Duox and TLR3 genes in Hermetia illucens larvae suppress zoonotic pathogens by modulating intestinal bacterial community homeostasis through immune signaling pathways.

The paper identifies a CHS-L gene responsible for anthraquinone biosynthesis in S. tora using genomics, transcriptomics, metabolomics, and biochemistry.

This study identifies RSH-1 as a lysosomal NADPH phosphatase that regulates ER proteostasis via mTOR signaling in C. elegans.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This paper introduces injectable nanoelectrodes for wireless deep brain stimulation in freely moving mice, showing behavioral changes through thalamic modulation.

This study shows that ATM-deficient cancer cells are more sensitive to the combination of olaparib and AZD6738, leading to cell death.

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

This study identifies EP2 as a key PGE2 receptor promoting neuroblastoma growth and shows that targeting it with small-molecule antagonists inhibits tumor growth in mice.

This study identifies a non-canonical Hippo pathway in yeast meiosis II that regulates spindle disassembly and cytokinesis through SPS1 and CDC15.

This study uses HETEROID to analyze how FAK, Rac, Rho, and Cdc42 inhibitors affect VSMC spheroid formation and morphology, revealing pathway-specific responses.

This study identifies copper hijacking by Sclerotinia sclerotiorum during infection and shows host resistance mechanisms involving copper homeostasis.

This study quantifies FtsZ dynamics in Bacillus subtilis and shows the Min system disassembles Z-rings and inhibits polar peptidoglycan remodeling.

This study shows CPR5 regulates ethylene signaling by interacting with ETR1's N-terminal domains and controlling mRNA nucleocytoplasmic transport.

This study develops a mouse model of glioblastoma (GBM) that replicates its genomic landscape and early stages, enabling research into prevention and treatment strategies.

The paper shows that ATPase binding at one end of the 20S proteasome allosterically opens the opposite gate, promoting symmetric and asymmetric proteasome configurations.

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

This study compares empathic responses in male and female mice and rats, finding no species difference in empathic behaviors but notable sex differences in mice.

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.

This paper develops a network-based method to identify reproducible radiomic features across different imaging settings and validates it using phantom and external datasets.

This study evaluates two tDCS optimization schemes for single and multi-target brain stimulation, showing that parameter settings significantly affect outcomes, especially in multi-target cases, and proposes improved weighted schemes.

This study shows TRIM21 and PHLDA3 regulate cross-talk between PI3K/AKT signaling and PPP metabolism, with implications for cancer therapy.

This study shows that Coxiella burnetii phase II can grow under normoxic conditions in ACCM-2 with tryptophan, and its transformant grows robustly without tryptophan, suggesting tryptophan and a temperature-sensitive signal are involved in normoxic growth.

This study examines how shift-work affects carotid artery health and cerebral blood flow in SHR and WKY rats, finding increased blood pressure, arterial thickening, and reduced blood flow.

This study identifies B7-H4 as a potential therapeutic target in bladder cancer, showing that anti-B7-H4 antibodies enhance immune responses and reduce tumor size in preclinical models.