B. Wang

This study reveals how ligands modulate the free energy landscape of the bacterial ribosome by altering its structural flexibility, suggesting entropic control as a general mechanism for regulating biomolecular machines.

The paper introduces M3-Seq, a single-cell RNA-sequencing platform for bacteria, and demonstrates its ability to reveal rare populations and stress response strategies.

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

This study uses a P1 bacteriophage to deliver CRISPR-Cas9 for targeted killing of Shigella flexneri in zebrafish larvae, reducing bacterial load and improving survival.

The paper uses molecular dynamics simulations to study how lipid nanodiscs release from charged nano-droplets during electrospray ionization, revealing two distinct release mechanisms.

This paper designs optimized monophasic TMS pulses that reduce coil heating while maintaining neuromodulation effectiveness, enabling higher pulse rates.

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

This paper demonstrates molecular computation on DNA-stored data using strand displacement reactions, achieving binary counting and Rule 110 computation on 4-bit registers.

This study addresses RT-PCR inhibition in picoliter double emulsion droplets by identifying lysate-induced probe cleavage as the main issue and showing heat lysis can alleviate it, enabling single-cell PCR in 20 pL droplets.

This study examines how chromium stress affects bacterial community structure and diversity in the rhizosphere soils of Iris pseudacorus using 16S rRNA sequencing.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.

This study compares yeast and mammalian Epsin localization and function, identifying differences in binding determinants and highlighting the role of poly-glutamine stretches.

This study identifies the host range of P1 phage with S tail fibre and shows its potential for delivering Cas9 antimicrobials into Shigella flexneri strains.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

The paper introduces RPSim, a computational framework to simulate electric fields in retinal implants, showing that 24 {micro}m resolution is achievable with optimized pixel designs and electrode configurations.

The paper introduces three novel methods for determining motor threshold with TMS, showing they outperform conventional approaches in accuracy and efficiency.

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

This study simulates TIS and related stimulation modalities on model cortical neurons to analyze E-field characteristics and neural responses, finding that TIS can cause conduction block and periodic activation at high E-field strengths.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study determines the structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators, revealing two distinct mechanisms to suppress channel activity.

The paper develops a framework to analyze and guarantee speed and correctness in DNA strand displacement reactions, experimentally validating predictions about leak and toehold occlusion.

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

The paper presents a power electronic system and magnetic nanoparticles enabling three-channel magnetogenetic neurostimulation with selective heating across different frequency ranges.

This study shows that CoQ deficiency in BAT activates the ISR and suppresses UCP1, yet increases whole-body metabolic rates and reduces weight gain on HFD.

This study identifies the dual role of AAGAB's tetramerization domain in stabilizing AAGAB and binding substrates during AP1/AP2 complex assembly.