C. Chen

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

This study identifies a regulatory loop involving MdMYB44-like, MdPYL8, and MdPP2CA that enhances salt and drought tolerance in apple by modulating ABA signaling.

The paper evaluates the impact of manufacturing changes on ARX788, an anti-HER2 ADC, using ICH Q5E guidelines and shows no adverse effect on product quality.

This paper develops human cervical Organ Chip models to study mucus production, host-microbiome interactions, and immune responses, showing they mimic in vivo conditions and respond to microbiome changes.

The paper reports low neutralizing antibody levels against influenza A H1N1 and H3N2 viruses in adults during the Omicron outbreak, emphasizing the need for influenza vaccination.

The paper quantifies UPF3A and UPF3B expression in mouse tissues, finding UPF3A is ubiquitously expressed, contradicting previous assumptions of limited expression.

The paper develops a tissue chip platform to screen radioprotective drugs for salivary gland protection and identifies lead compounds with potential radioprotective effects.

This study shows that EETs and sEH inhibitors prevent CVB3-induced myocarditis by enhancing type I interferon signaling and improving viral resistance.

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This paper shows that silencing NbCORE in older Nicotiana benthamiana plants significantly increases agroinfiltration productivity by improving transient protein expression.

This study shows that proline catabolism is essential for Candida albicans pathogenicity, as mutations in proline utilization genes reduce virulence in animal models.

This study shows that IL-17 overactivation in C. elegans reduces lifespan and stress tolerance by inhibiting a protective transcriptional network involving NHR-49 and MDT-15.

This paper uses the Event-based Vision Sensor (EVS) to quantify millisecond-scale behaviors of plankton in both natural and laboratory settings, revealing rhythmic motion patterns and species-specific periodicities.

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

This study investigates the origin and evolution of the mosquito male-determining factor Nix across Culicinae subfamily species, finding it originated 133-165 MYA and evolved faster than related factors.

This study optimizes antimicrobial peptides to enhance activity against drug-resistant bacteria and biofilms while reducing cytotoxicity.

This study identifies MDF as a splicing factor regulating root meristem function in Arabidopsis by controlling splicing of RSZ33, ACC1, and SR34, balancing stemness and stress response.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

The paper models surface nano-ridge patterns in petal epidermal cells using a morphoelastic bi-layer model, showing how mechanical factors influence pattern formation.

This study identifies the C-terminal domains of RNase H and integrase as regulators of virus release and autoprocessing in a defective HIV-1 variant with specific mutations.

The paper uses 3D reconstructions to show that honey bee swarms follow a strength-mass scaling law, where each layer's weight scales with its mass to the 1.5 power.

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

This study evaluates the effectiveness of a bivalent subunit vaccine containing Omicron BA.4/BA.5 and BA.1 subvariants as a booster, finding it provides the highest neutralizing titers against BA.4/BA.5 in mice.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

The paper shows that inflammation causes age-related loss of tissue-resident macrophages, which cannot be replaced by hematopoietic stem cell-derived cells, and that reducing inflammation prevents this loss and improves liver aging.

The paper identifies and characterizes unannotated proteins in green lineage species, finding many with novel structures and potential plastid functions.

The paper investigates how crossover (CO) distribution in maize becomes U-shaped during meiosis, finding that chromatin state, not DNA methylation or sequence polymorphism, shapes the final CO landscape.