C. Chen

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

This study shows that UHRF1 upregulation drives exosome release and tumor progression in osteosarcoma by promoting metastasis and cell mobility.

This study compares symbiont population differentiation in deep-sea mussels with different ecological niches, finding that habitat homogeneity and mixotrophy reduce geographic structuring of symbiont strains.

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

The paper analyzes hydrothermal vent species assemblage networks in the Northwest Pacific to identify regional connectivity patterns and their implications for conservation.

The paper reports a cryo-EM structure of a PmrA-dependent transcription activation complex and shows how PmrA interacts with DNA and RNA polymerase to activate gene transcription.

The paper uses GIS and multivariate statistical methods to identify anthropogenic heavy metal sources in Hong Kong marine sediments, finding three distinct sources: industrial discharges, natural sources, and municipal/industrial wastewater.

This study identifies 933 heat tolerance genes in Chlamydomonas reinhardtii through genome-wide mutant screens, showing 50% have orthologs in crops and Arabidopsis mutants are heat sensitive.

The paper uses machine learning to identify key chromatin features that determine meiotic recombination sites in plants, finding that three features can predict crossover sites with 90% accuracy.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This study shows UPF3A is not required for NMD in mouse pluripotent and somatic cells, and may only weakly promote NMD in some tissues.

Glycan trimming of HIV-1 Env immunogens improves vaccine-induced neutralizing antibody responses in small animals and primates.

This study shows that structural flexibility in MAD1's hinge region is crucial for efficient MCC assembly and SAC signaling, with implications for understanding mitotic checkpoint function.

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

This study shows that the Omicron BA.1.1 variant causes less severe disease, lower viral shedding, and reduced tissue replication compared to D614G and Delta variants in a feline model.

This study shows that overexpressing connexin43 in bone marrow-derived stromal stem cells promotes osteogenesis and angiogenesis, enhancing bone regeneration in a rat model of glucocorticoid-induced osteonecrosis.

This study sequenced three Phakopsora pachyrhizi genomes, revealing high transposable element content and its correlation with host-range adaptation in legumes.

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

This study measures amygdala and ERC atrophy rates in preclinical Alzheimer's disease using MRI and reconstructs 3D tau pathology distributions, finding amygdala atrophy comparable to ERC and suggesting it as a potential biomarker.

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

This study shows that sickle RBC-derived extracellular vesicles activate endothelial cells and enhance RBC adhesion via von Willebrand factor, with implications for SCD treatment.

This study shows that the abundance of SAC proteins like Bub1 affects their recruitment to kinetochores and SAC signaling activity, with lower abundance reducing signaling and higher abundance increasing it.

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

This paper introduces a compact intraoral transducer for full-mouth photoacoustic/ultrasound imaging of periodontal pockets, demonstrating its clinical relevance with in vivo imaging accuracy within 7% of clinical measurements.

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

The paper introduces a CNN model to predict RBD-hACE2 binding affinity changes for SARS-CoV-2 variants, achieving high accuracy and identifying variants with improved binding affinity.

This study shows an intranasal nanoemulsion-adjuvanted S-2P vaccine induces strong systemic, cell-mediated, and mucosal immunity in mice and protects hamsters from SARS-CoV-2 infection.