C. Xu

This study identifies IL24 as a tissue repair pathway parallel to IFN-mediated host defense, showing its role in epithelial and mesenchymal regeneration after injury.

This paper identifies HY-008, a PDGFRα inhibitor with high BBB permeability, as effective against glioblastoma in vitro and in vivo, showing improved survival and synergy with TMZ.

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

The paper introduces a method to detect frequency-dependent selection by analyzing genotype similarity's effect on fitness components using regression analysis in Arabidopsis and damselfly data.

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

This paper quantifies the human cost of global warming by estimating how many people will be outside the historical climate niche under different warming scenarios.

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

The paper shows that waterbird community composition strongly predicts HPAI H5 occurrence in wild birds across different epidemics, with similar patterns observed for H5N8 and H5N1.

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

This study investigates DNA methylation inheritance in Pacific oysters, finding that half of parental methylation differences are passed to offspring and revealing sex-specific methylation patterns linked to Rho signaling.

This study uses molecular simulations to show that bevirimat and IP6 bind to HIV-1 immature lattice without cooperativity and reveal independent dynamics of SP1 regions.

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

This study identifies the mitochondrial RNA granule as a protective mechanism against manganese toxicity by showing its downregulation enhances cell survival.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper investigates how compensation between paralogs evolves in plant stem cell control, showing that a single amino acid change and cis-regulatory variation can reduce compensatory ability in tomato.

This paper develops a cryoET processing pipeline using CNNs to characterize the morphology and structure of influenza viruses, improving analysis throughput and enabling subtomogram averaging of glycoproteins.

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.